Bupivacaine Verus Pethidine for Post Cesarean Section Pain Relief

Subrectal and Subcutaneous Wound Infiltration With Bupivacaine Versus Pethidine for Postcesarean Section Pain Relief: a Randomized Clinical Trial

Status

Completed

Phases

Phase 2Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03652116

Enrollment

Registered

2018-08-29

Start date

2017-04-21

Completion date

2018-08-01

Last updated

2018-08-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obstetric Pain

Brief summary

The aim of this study is to compare between the effect of wound infiltration with bupivacaine or pethidine for post cesarean section pain relief.

Interventions

DRUGWound infiltration by Bupivacaine

Subcutaneous and subrectal infiltration with 0.25 % Bupivacaine diluted in 20 ml normal saline before closure of the wound

DRUGWound infiltration by Pethidine

Subcutaneous and subrectal infiltration with 50 mg pethidine diluted in 20 ml normal saline before closure of the wound

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Intervention model description

Participants will be randomized to local infiltration of cesarean section wound with either bupivacaine or pethidine; with follow up of postoperative pain relief.

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 40 Years

Healthy volunteers

Inclusion criteria

* Mode of delivery: Cesarean section. * Gestational age: 37-40 weeks. * Type of anaesthesia: Spinal anaesthesia. * No past history of any medical disorder or other medical complications during pregnancy.

Exclusion criteria

* Women with known hypersensitivity to bupivacaine or pethidine. * Women delivered vaginally. * Women delivered under general anaesthesia. * Women with known neurological or psychological disease.

Design outcomes

Primary

Measure	Time frame	Description
Postoperative wound pain: VAS	first 24 hours postoperatively	Postoperative wound pain will be assessed using visual analogous scale (VAS) ranging from 0 (no pain) to 10 (worst pain imaginable). Mean values will be calculated and compared between the three groups

Secondary

Measure	Time frame	Description
Total dose of opioid drugs needed	first 24 hours postoperatively	Total dose of extra opioid drugs needed to achieve postoperative analgesia
Incidence of nausea and vomiting	first 24 hours postoperatively	Number of patients experiencing nausea and vomiting
Incidence of urine retention	first 24 hours postoperatively	Number of patients experiencing urinary retention
Incidence of hypotension	first 24 hours postoperatively	Number of patients experiencing hypotension

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 25, 2026