Effects of Nicotine in Tobacco Smokers

Mechanisms Linking Obsessive-Compulsive Symptoms and Tobacco Dependence

Status

Completed

Phases

Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03651869

Enrollment

221

Registered

2018-08-29

Start date

2019-02-04

Completion date

2023-03-23

Last updated

2023-07-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Smoking, Tobacco, Smoking (Tobacco) Addiction

Keywords

Smoking

Brief summary

This study will examine mechanisms linking Obsessive-Compulsive Disorder symptomatology to tobacco dependence.

Interventions

DRUGCigarette 1

Cigarette containing between 0mg nicotine and the conventional amount of nicotine (0.8mg)

DRUGCigarette 2

Cigarette containing between 0mg nicotine and the conventional amount of nicotine (0.8mg)

DRUGPatch 1

A patch containing between 0mg nicotine and the conventional amount of nicotine (21mg)

DRUGPatch 2

A patch containing between 0mg nicotine and the conventional amount of nicotine (21mg)

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

21 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* At least 21 years old * Daily smoking at least 2 years

Exclusion criteria

* Currently pregnant or breastfeeding.

Design outcomes

Primary

Measure	Time frame	Description
Smoking Urge	Throughout study completion, an average of two weeks.	Smoking urge is measured using questionnaires that ask about a desire to smoke.

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026