Lung Injury, Acute, Ventilator Adverse Event, Ventilator-Induced Lung Injury
Conditions
Brief summary
Respiratory complications range from 8% to 79% of the frequency after open heart surgery where the patient is on-pump operated by cardiopulmonary machine. There were many changes in physiology due to anesthesia and cardiac surgery which cause volume and barotrauma complications with mechanical ventilation. These complications increase cost by prolonging morbidity and morbidity as well as hospital stay. Intraoperative and postoperative mechanical ventilation strategies can prevent these complications. CPB stimulates the systemic inflammatory response to the secretion of neutrophil, endotoxin and proinflammatory cytokines in the complex, increasing the permeability of the capillaries. Although coronary artery bypass graft surgery (CABG) is associated with a 0.4% to 2.0% acute respiratory distress syndrome (ARDS), mortality is quite high. Lung-protective ventilation strategies commonly used for prevention of ARDS. Ferrando et al. have proposed pulmonary ventilation with a tidal volume (TV) of less than 10 mL / kg as a pulmonary intraoperative protective ventilation strategy. Investigators aimed to compare oxygenation and ventilation parameters with respiratory mechanics in patients who underwent open heart surgery and were ventilated with 6 ml / kg tidal volume and 8 ml / kg TV, which were recommended as lung protective ventilation strategies during anesthesia.
Interventions
DEVICEMechanical ventilation
Patients will be ventilated with anesthesia machine according to the group they belong to
Sponsors
Kocaeli University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Undergoing Cardiopulmonary bypass
Exclusion criteria
* Severe COPD * Chronic Anemia * Active Smoker * Chronic kidney Disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change of arterial carbondiokside pressure levels | from the beginning of operation to 6th hour of post-extubation | Investigators will compare the changes in arterial carbondiokside levels in arterial blood gas samples |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Changes in respiratory parameters | from the beginning of the operation to the end of the surgery | airway pressures will be continuously assessed |
| Changes in Invasive blood pressures | from the beginning of the operation to the end of the surgery | Blood pressure will be continuously recorded and assessed due to time intervals |
| Changes in heart rate | from the beginning of the operation to the end of the surgery | Heart rate will be continuously recorded and assessed due to time intervals |
| Changes in central venous pressure | from the beginning of the operation to the end of the surgery | Continous central venous pressure will ve recorded and assessed due to time intervals |
Countries
Turkey (Türkiye)
Outcome results
None listed