Endothelial Function, Hyperglycemia
Conditions
Keywords
exercise, glucose, vascular function
Brief summary
The main purpose of this study is to determine if exercise preserves vascular function during hyperglycemia. All subjects will consume a sugary beverage three times daily for seven days. Subjects will be randomly assigned to either the glucose with (GLU+EX) or without (GLU) structured exercise group.
Detailed description
Acute (oral glucose tolerance test) and chronic (type 2 diabetes) hyperglycemia are associated with impaired endothelial function. Both a single bout of exercise and chronic exercise training are associated with improvements in vascular endothelial function. It remains unknown if exercise can preserve vascular endothelial function during hyperglycemia.
Interventions
BEHAVIORALGLU+EX
Subjects will complete 45 minutes of recumbent cycling at 60-65% of age-predicted maximal heart rate five times over seven days while ingesting a 75g glucose beverage three times daily.
DIETARY_SUPPLEMENTGLU
Subjects will consume a 75g glucose beverage three times daily over a seven-day period.
Sponsors
University of Iowa
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Intervention model description
Randomized
Eligibility
Sex/Gender
MALE
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
\- Healthy young men 18-35 years of age.
Exclusion criteria
* Hypertension, * Hyperlipidemia, * Smoking, * Heart disease, * Chest pain upon exertion, * Previous heart surgeries or history of arrhythmias, * Diabetes, * Obesity (body mass index ≥30kg/m2), * Kidney disease, * Pulmonary disease, * Autonomic disorders, * Individuals whom engage in structured exercise (≥30min, ≥2d/wk), * Current use of medications which influence outcome measures
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Vascular Endothelial Function | Before and after the seven-day intervention in both groups. | Brachial artery flow-mediated dilation (%), measured via Doppler ultrasound, will be assessed before and after the intervention. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Central Blood Pressure | Before and after the seven-day intervention in both groups. | Aortic blood pressure will be derived from radial artery pressure wave measurements (via applanation tonometry) during resting conditions. |
Other
| Measure | Time frame | Description |
|---|---|---|
| Physical Activity | Continuously throughout the seven-day intervention. | Steps per day will be recorded via accelerometry throughout the intervention in both groups. |
| Caloric Consumption | Continuously throughout the seven-day intervention. | Subjects will record their dietary intake throughout the intervention. |
Countries
United States
Outcome results
None listed