Twin Diseases
Conditions
Brief summary
Fetal medicine in China is still a new, young discipline, and the development is very rapid. After nearly 10 years of development, the clinical diagnosis and treatment guidelines of some complicated twin diseases has been established , but they are still needed to be improved. Through this study, the investigators expect to achieve better prediction indicators and early intrauterine precise diagnosis of complicated twin diseases. Also, better procedures of implementing effective intrauterine intervention and assessing the safety and effectiveness of intrauterine intervention are anticipated to be established.
Detailed description
A better guideline for complicated twin diseases are anticipated to be established in China. Molecular genetics and imaging technology are applied to evaluate the outcome and prognosis of intrauterine intervention for complex twin diseases. 3D printing technology is used to assist the preoperative evaluation of fetal intrauterine intervention. Better fetal intrauterine intervention technique and prognosis evaluation are expected to be established.
Interventions
PROCEDUREFetoscope technique
Intrauterine intervention with fetoscope technique will be applied to treat complex twin diseases with intention to improve the prognosis of patients.
Sponsors
Shengjing Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
Pregnancy women with complicated twin diseases, who are able to withstand risks of intrauterine treatments and informed consent.
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* Pregnancy women with complicated twin diseases who are able to withstand intrauterine treatment and consent informed.
Exclusion criteria
* Pregnancy women who refuse intrauterine treatment.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Gene expression of fetuses | At 20 week of gestational age | DNA methylation, histone acetylation etc. assessed by analyses of fetal blood and amniotic fluid. |
| Change of volume of amniotic fluid in Milliliter | At every two week from the sixteenth week of gestational age to delivery of babies | Measured by doctors of sonography |
| Change of umbilical artery blood flow | At every two week from the sixteenth week of gestational age to delivery of babies | Measured by doctors of sonography |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Neurodevelopment at early childhood | At age of 1 year old | Including adaptive, gross motor, fine motor, language, and social function; assessed using Gesell Developmental Schedules. |
Countries
China
Contacts
Primary ContactCaixia Liu
Backup ContactShaojiang Liu
Outcome results
None listed