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Heated Circuit for One-lung Ventilation

Effect of Heated-humidified Circuit on Arterial Oxygenation in Patients Undergoing One-lung Ventilation for Thoracoscopic Surgery

Status
UNKNOWN
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT03649386
Enrollment
104
Registered
2018-08-28
Start date
2018-09-01
Completion date
2019-12-01
Last updated
2018-08-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

One-lung Ventilation, Oxygenation, Temperature

Brief summary

One-lung ventilation interrupts oxygenation. The effect of heated humidifed breathing circuit on arterial oxygenation during one-lung ventilation has not been investigated. The investigators will investigate the effect of the heated humidifed breathing circuit on oxygenation during one-lung ventilation in patients undergoing thoracoscopic surgery.

Interventions

DEVICEHeated and humidified breathing circuit on

Heated and humidified breathing circuit will be turned on.

DEVICEHeated and humidified breathing circuit off

Heated and humidified breathing circuit will be turned off.

Sponsors

Keimyung University Dongsan Medical Center
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Age
19 Years to 80 Years
Healthy volunteers
No

Inclusion criteria

* American Society of Anesthesiologist class I-II * Patients scheduled for one-lung ventilation for thoracoscopic surgery

Exclusion criteria

* Obesity * Severe obstructive or restrictive lung disease * Preoperative oxygen supply * Preoperative intubated state or under mechanical ventilatory support * Baseline arterial partial pressure of oxygen (PaO2) \< 70 mmHg * Symptomatic coronary or peripheral arterial disease * Renal failure * Preoperative continuous infusion of inotropes or vasopressor * Pregnancy

Design outcomes

Primary

MeasureTime frameDescription
Arterial oxygenationAt 30 minutes after one-lung ventilationArterial oxygenation (mmHg) will be measured by arterial blood analysis.

Secondary

MeasureTime frameDescription
Mean arterial pressureAt 0, 15, 30, 45, and 60 minutes after one-lung ventilationMean arterial pressure (mmHg) will be measured.
Heart rateAt 0, 15, 30, 45, and 60 minutes after one-lung ventilationHeart rate (beats/min) will be measured.
TemperatureAt 0, 15, 30, 45, and 60 minutes after one-lung ventilationBody temperature (°C) will be measured.
Central venous pressureAt 0, 15, 30, 45, and 60 minutes after one-lung ventilationMean central venous pressure (mmHg) will be measured by a central venous catheter.
Cardiac indexAt 0, 15, 30, 45, and 60 minutes after one-lung ventilationCardiac index (l/min/m\^2) will be measured by pulse-contour analysis.
Arterial oxygenationAt 0, 15, 45, and 60 minutes after one-lung ventilationArterial oxygenation (mmHg) will be measured by arterial blood analysis.
Pressure plateauAt 0, 15, 30, 45, and 60 minutes after one-lung ventilationPlateau pressure of ventilation (cmH2O) will be measured.
Arterial carbon dioxideAt 0, 15, 30, 45, and 60 minutes after one-lung ventilationArterial carbon dioxide will be measured.
Arterial blood acidosisAt 0, 15, 30, 45, and 60 minutes after one-lung ventilationArterial blood acidosis will be measured.
Oxygen saturation of arterial bloodAt 0, 15, 30, 45, and 60 minutes after one-lung ventilationOxygen saturation of arterial blood (%) will be measured.
Pressure peakAt 0, 15, 30, 45, and 60 minutes after one-lung ventilationPeak pressure of ventilation (cmH2O) will be measured.

Contacts

Primary ContactHyun-Chang Kim, MD Ph
onidori1979@gmail.com+821028862876

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026