Post-stroke Cognitive Impairment
Conditions
Keywords
Noninvasive Brain Stimulation, Repetitive Transcranial Magnetic Stimulation, Transcranial Direct Current Stimulation
Brief summary
Repetitive transcranial magnetic stimulation (rTMS) or transcranial direct current stimulation (tDCS) has been used for the modulation of post-stroke cognitive impairment patients' cognitive function by altering the cortical excitability. Recently, more challenging approaches, such as stimulation of two or more sites or use of dual modality have been studied in stroke patients. In this study, simultaneous stimulation using both facilitatory rTMS (10Hz) and anodal or cathodal tDCS (dual-mode stimulation) over bilateral dorsolateral prefrontal cortices (DLPFCs) was investigated to compare its modulatory effects with single facilitatory rTMS stimulation in post-stroke cognitive impairment patients.
Interventions
10Hz rTMS over the left DLPFC and anodal tDCS over the right DLPFC are simultaneously stimulated.
10Hz rTMS over the left DLPFC and cathodal tDCS over the right DLPFC are simultaneously stimulated.
10Hz rTMS over the left DLPFC and sham tDCS (no stimulation) over the right DLPFC are simultaneously stimulated.
Sponsors
Samsung Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* First-ever stroke patients * Subacute stage (less than 4 weeks) * Who can perform the 2-back verbal and non-verbal working memory task
Exclusion criteria
* K-MMSE score under 9 * Major active neurological disease or psychiatric disease * A history of seizure * Metallic implants in their brain
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Accuracy of 2-back verbal working memory task | Change from Pre-intervention at 2 months | Accuracy (percentile) of 2-back verbal working memory task |
Countries
South Korea
Outcome results
None listed