Multiple Sclerosis
Conditions
Keywords
facilitation technique, multimodal evoked potentials (mmEP) in multiple sclerosis, motor evoked potential (MEP) in multiple sclerosis
Brief summary
Investigating the change in Test- Retest- reliability in healthy individuals when applying a modified easy to use facilitation technique compared to standard facilitation technique and analyzing sensitivity and specificity in patients with multiple sclerosis regarding detection of pathologic results
Interventions
DIAGNOSTIC_TESTMEP using standard facilitation technique
measuring of MEP using standard facilitation technique according to the Guidelines of International Federation of Clinical Neurophysiology
DIAGNOSTIC_TESTMEP using modified facilitation technique
measuring of MEP using modified facilitation technique (application of additional 8-12x magnetic stimuli for arms and legs)
Sponsors
University Hospital, Basel, Switzerland
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
for healthy individuals: * Ability to understand the purpose and risks of the study, provide signed and dated informed consent * Between 18 and 65 year of age * No neurologic or psychiatric comorbidity requiring continous treatment * No previous damage of central nervous System Inclusion Criteria for patients: * Ability to understand the purpose and risks of the study, provide signed and dated informed consent * Between 18 and 65 year of age * patients with inflammatory diseases of the central nervous system (CNS) or multiple sclerosis appointed for routine MEP diagnostic at the Department of Clinical Neurophysiology, University Hospital Basel
Exclusion criteria
* Contraindication for measuring of motoric evoked potentials (MEP): metal implants (pacemaker, stents); known epilepsy oder previous epileptic fit * Known disease of the peripheral nervous system (polyneuropathy)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Test- Re-Test reliability when using modified facilitation technique (compared to standard facilitation technique) in healthy individuals | measuring time 2 (75 minutes) maximal 1 month later than measuring time 1 (75 minutes) | Determination of mean intra-individual difference between measuring time 1 and measuring time 2 and calculation of standard deviation |
| comparison of sensitivity and specificity of modified facilitation technique and standard facilitation technique in patients with multiple sclerosis | 1 measuring time (90 minutes) | Determination on the basis of the standard values (established in healthy individuals) in how many patients a pathological result with the modified facilitation technique and the standard facilitation technique is present. Using a a cross-tabulation, the sensitivity and specificity of the modified facilitating technique compared to the standard facilitation technique is measured |
Countries
Switzerland
Outcome results
None listed