Observe Effect of Antioxidant on Sperm DNA Fragmention
Conditions
Brief summary
Observational study to see the effect of use of natural Antioxidant supplement on sperm DNA fragmentation. Subjects will take the natural antioxidant for 3 months prior to repeat testing.
Detailed description
Male patients will be recruited based on having a high DNA fragmentation (chromatin \>16) no other severe male factor infertility (\>5million/ml, count, \> 10%motility and \>1% morphology) and sufficient ejaculate sperm for ICSI (no surgically removed sperm or history of vasectomy reversal). Patients will be provided the natural antioxidant supplementation by the sponsor. Patients will take 1 capsule orally 3 times a day for a full 12 weeks. Sperm DNA structure will be re-assessed after completion of 12 weeks of antioxidant to compare to baseline sperm DNA structure collected prior to starting regimen of supplement daily
Interventions
DIETARY_SUPPLEMENTNatural Antioxidant supplement
1 capsule orally three times a day for 12 weeks
Sponsors
Colorado Center for Reproductive Medicine
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
MALE
Age
18 Years to 55 Years
Inclusion criteria
-Sperm Chromatin \>16%, sufficient ejaculate sperm for ICSI
Exclusion criteria
* Severe male factor infertility
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Sperm DNA fragmentation | 12 weeks | Direct comparison of sperm DNA fragmentation pre and post natural antioxidant exposure |
Countries
United States
Outcome results
None listed