Vascular Diseases
Conditions
Keywords
vascular ischemic lesion
Brief summary
The study aims to investigate the behavioral effects, neural correlates and functional connectivity of cognitive training in patients with stroke
Detailed description
The study will investigate the effects of two cognitive training strategies on behavior, neural correlates and functional connectivity of patients with vascular lesions. The first strategy is associated to the ability to apply efficient organizational semantic category strategy to a list of words. This strategy will be trained in activities similar to everyday life activities. There will be in total 5 sessions, two for measuring the generalization effects before and after training and three sessions to apply the semantic strategy in order to improve encoding and episodic memory performance. The second strategy is related to the ability to remember face-names and the strategy will involve the identification of a salient face feature, creation of a nickname and association of the nickname to the real name. There will be 5 sessions in total, two for measuring the generalization effects before and after training and three sessions to apply the face-name association strategy in order to improve encoding and episodic memory performance. These two cognitive training procedures will be carried out in two separate moments. Before and after each procedure all participants will be examined by functional MRI during resting state and during a active task using a memory encoding paradigm. The same procedure will be carried out with normal control participants.
Interventions
BEHAVIORALCognitive training
Five sessions of semantic strategy training and face-name association training
BEHAVIORALControl Condition
Five sessions of active control information and education
Sponsors
University of Sao Paulo
São Paulo State University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* people with chronic vascular ischemic lesions (more than 6 months)
Exclusion criteria
* vascular hemorrhages, stenosis, psychiatric problems
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline memory performance at 6 months | up to 24 weeks after intervention | Hopkins Verbal Learning Test (episodic memory test total immediate score 48 and delayed score12) and fMRI active task (news recall immediate and delayed score 12) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline everyday life activity performance at 6 months | up to 24 weeks of intervention | Generalization questionnaire (questions on difficulties in everyday memory total score 12) |
Countries
Brazil
Outcome results
None listed