Bronchiectasis
Conditions
Keywords
Bronchiectasis, multi-centered registry
Brief summary
The investigators meant to establish a multi-centered bronchiectasis patient registry for Chinese bronchiectasis patients. This would be the first bronchiectasis registry in China. Patients with all kinds of bronchiectasis would be enrolled.
Detailed description
A multi-centered bronchiectasis patient registry would be founded, which will include patients from three teaching hospital (Ruijin Hospital, Zhongshan Hospital and Shanghai Pulmonary Hospital) in Shanghai at the beginning. The network will be promoted to other cities and different places in China. Patients with bronchiectasis would be enrolled and detailed information would be recorded. Follow-up of patients would provide more information on the prognosis of disease. Optimal treatment studies for the patients will be initiated one by one based on the network. The investigators are committed to promoting clinical research and education in bronchiectasis, through sharing of protocols, research idea and expertise.
Interventions
None listed
Sponsors
Ruijin Hospital
Shanghai Zhongshan Hospital
Shanghai Pulmonary Hospital, Shanghai, China
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* Patients diagnosed with bronchiectasis according to 'non-cystic fibrosis bronchiectasis guideline' published by British Thoracic Society in 2010. * Patients who are willing to sign the consent form and participate in the study.
Exclusion criteria
* Patients with incomplete essential information, which is needed for the integrity of data analysis. Essential information include CT images, respiratory sample cultures, spirometry and exacerbation history for at least one year. * Patients under 18 years old.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of patients enrolled in the registry | 3 years | To establish a multi-centered bronchiectasis registry in Shanghai |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Exacerbation | up to 3 years | Exacerbation was defined as the use of antibiotics or even hospitalization due to the worsening of symptoms or emergence of new symptoms. |
| Aetiology | at baseline | To analysis the possible cause of bronchiectasis in Shanghai, China. |
| Microbiology | At least 1 year before enrollment and 3 years during the follow-up | Sputum or bronchoalveolar lavage fluid culture |
| Comorbidity | At baseline and updated every year for up to 3 years | Comorbidity would be recorded. |
| Lung Function (FEV1, FVC, FEV1% pred, FVC% pred etc.) | recorded at baseline and re-tested every year, up to 3 years. | Lung function would be tested by spirometry when patients visit the clinic. |
| Bronchiectasis severity Score (BSI) | At baseline and updated once a year for 3 years | The scale is presented online. It consists of 9 items including Age, BMI(Body Mass Index), % FEV1 Predicted, Previous Hospital Admission in the past 2 years, number of exacerbations in previous year, MRC Breathlessness Score, Pseudomonas Colonisation, Colonisation with other organisms,affected lobes. 0-4 Mild Bronchiectasis. 5 - 8 Moderate Bronchiectasis. 9 + Severe Bronchiectasis. |
| E-FACED score | At baseline and updated once a year for 3 years | It consists of 6 items including exacerbation history in the past year, % FEV1 predicted, Age, Chronic colonization by Pseudomonas aeruginosa, n° of pulmonary lobes affected,and Dyspnea (measured by mMRC score) mild: 0-3 points, moderate: 4-6 points; and severe: 7-9 points |
| Mortality | 3 years | — |
| modified Medical Research Council (mMRC) dyspnea score | At baseline and updated once a year for 3 years | 1. \- Not troubled by breathlessness except on strenuous exercise 2. \- Short of breath when hurrying or walking up a slight hill 3. \- Walks slower than contemporaries on level ground because of breathlessness, or has to stop for breath when walking at own pace 4. \- Stops due to breathlessness after walking 100m 5. \- House bound due to breathlessness, or breathless on dressing or undressing. |
| Quality of Life Questionnaire-Bronchiectasis | At baseline and updated once a year for 3 years | The questionnaire asks patients questions about their current state of health. It could be downloaded from the website online. |
Countries
China
Contacts
Primary ContactJin-Fu Xu, MD
Outcome results
None listed