Diet Modification, Nutrient; Excess, Obesity
Conditions
Keywords
Meal replacement, calorie restriction, body weight
Brief summary
The present study was designed to evaluate the impact of a nutritionally balanced conventional meal replacement diet with caloric restriction (intervention for 8 weeks) in Taiwanese obese subjects. Various parameters like anthropometric (body weight, body fat, waist circumference), lipid profile (TC, LDL-c and TG), cardiovascular risk factors, glycemic and oxidative markers as well as renal and hepatic markers were evaluated.
Detailed description
The present study was designed to evaluate the impact of a nutritionally balanced conventional meal replacement diet (rich in soy/pea protein and soluble fibers) with caloric restriction in Taiwanese obese subjects. Obese subjects (BMI\>27; n=50, male 23, female 27) were recruited and requested to replace two meals/day (breakfast and lunch or dinner) by balanced nutritional meal replacement diet (equal to 240 kcal) for 8 weeks with one regular meal and make sure the daily target calorie limit should be less than 1500 kcal/day for men and 1200 kcal/day for women.
Interventions
DIETARY_SUPPLEMENTMeal replacement diet
Obese subjects were requested to replace two meals/day (breakfast and lunch or dinner) by balanced nutritional meal replacement diet (equal to 240 kcal) for 8 weeks with one regular meal and make sure the daily target calorie limit should be less than 1500 kcal/day for men and 1200 kcal/day for women.
Sponsors
Chung Shan Medical University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Masking description
it's a Open-label clinical trial
Intervention model description
To evaluate the impact of a nutritionally balanced conventional meal replacement diet (rich in soy/pea protein and soluble fibers) with caloric restriction in Taiwanese obese subjects.
Eligibility
Sex/Gender
ALL
Age
20 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy obese subject (BMI \>27) * Aged between 20 to 80 of both genders with a desire to lose weight.
Exclusion criteria
* Subjects with cancer * Hyperglycemic (diabetic) * Hypertension, * Stroke * Renal dysfunction * Cardiac or hepatic dysfunctio * allergic to the dairy product and eating disorders * Pregnancy, nursing (lactating), chain smokers and heavy alcoholic subjects
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Calorie intake in obese subjects | 8 weeks | Intervention with calorie restricted meal replacement diet for 8 weeks to check the changes in calories (Kcal) |
| Anthropometric parameter | 8 weeks | Intervention with calorie restricted meal replacement diet for 8 weeks to check the change in body weight (kg) |
| Cardiovascular (CV) risk factors | 8 Weeks | Intervention with calorie restricted meal replacement diet for 8 weeks to check the changes in CV risk factor like Homocysteine (umol/L) |
| Glycemic markers | 8 Weeks | Intervention with calorie restricted meal replacement diet for 8 weeks to check the changes in Glycemic marker like FBG (mg/dL) |
| Lipid profile | 8 weeks | Intervention with calorie restricted meal replacement diet for 8 weeks to check the changes in total cholesterol (mg/dl) |
Countries
Taiwan
Outcome results
None listed