CRE-induced SBO
Conditions
Brief summary
Chronic radiation enteropathy (CRE) is a major issue for long-term cancer survivors. The aim of this study was to clarify the diagnostic and therapeutic effect of the Gastrografin (GG) challenge for patients with CRE induced small bowel obstruction SBO.
Interventions
DRUGGastrografin
Patients with CRE-induced SBO or ASBO both received GG challenge.
Sponsors
Jinling Hospital, China
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* with a first diagnosis of CRE combined with SBO and ASBO that was determined by clinical history, computed tomography (CT) manifestation, and confirmed by intraoperative and histologic findings. * radiation therapy completed at least 6 months before enrolment.
Exclusion criteria
* a colostomy or ileostomy; * large bowel obstruction; * with a known history of either allergy or hypersensitivity to iodinated contrast agents; * with signs of strangulation; * metastatic disease; * obstruction within 4 weeks after a recent operation or serious comorbidity.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The rate of successful conservative treatment | 5 days | The rate of patients who need for operative intervention within 48 hours of randomization. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The time to resolution | 2 weeks | The time to resolution of ASIO (flatus and bowel motion). |
| The length of hospital stays | 2 weeks | The length of hospital stays (in hours, calculated from the hospital admission to resolution of intestinal obstruction). |
Outcome results
None listed