Adiposity, Iron-deficiency
Conditions
Brief summary
Adiposity is a state of sub-clinical inflammation, thus hepcidin is increased in adiposity, often leading to iron deficiency in this population group. Central adiposity is generally considered having a greater negative effect on health compared to peripheral adiposity. Whether this can be also seen in hepcidin and thereby in iron absorption is uncertain.
Interventions
OTHERStable iron isotopes
Participants have to consume a test meal containing stable iron isotopes in order to determine iron absorption
Sponsors
American University of Beirut Medical Center
Swiss Federal Institute of Technology
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
* either normal-weight (BMI 18-25kg/m2) or overweight/obese (BMI 28-50kg/m2) with either central or peripheral fat deposits based on DEXA
Exclusion criteria
* Iron Supplement or antibiotic intake within 2 weeks before study start * diagnosed chronic disease or gastrointestinal disorders * regular use of medication (except contraceptives) * pregnancy * lactation * smoking * blood donation or surgery within the last 4 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fractional and total iron absorption | 14days after the administration of the test meal |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Serum ferritin | at baseline | iron status |
| Serum TfR | at baseline | iron status |
| Serum Hepcidin | at baseline | — |
| Serum AGP | at baseline | inflammation status |
| Serum IL-6 | at baseline | inflammation status |
| Serum CRP | at baseline | inflammation status |
Countries
Lebanon
Outcome results
None listed