Alzheimer Dementia, Posttraumatic Stress Disorder, Traumatic Brain Injury
Conditions
Keywords
Alzheimer Dementia, PTSD, MRI
Brief summary
The purpose of this study is to learn about how trauma, posttraumatic stress disorder (PTSD), and mild traumatic brain injury that can occur during deployment affect the brain. The investigators also want to learn how PTSD and mild traumatic brain injury can affect the chance of developing Alzheimer disease later in life. The investigators will study this by using magnetic resonance imaging and positron emission tomography scans to obtain pictures of the brain.
Interventions
DEVICEMRI
You will be asked to undergo a scan of your brain called an MRI. The MRI scan can measure the functioning of your brain.
DEVICEPET
You will be asked to undergo a scan of brain called a positron emission tomography (PET) scan. The PET scan is a test that uses radioactive glucose (sugar) and a computer to create images of how your brain is functioning. Abnormal cells in the body use glucose at a different rate than normal cells and this allows the scanner to create a detailed picture of how your body is working.
DEVICE18F-Florbetapir
At the Duke University PET Center you will be in a quiet dimly lit space with only ambient room sound, with your eyes open and ears unplugged. Your safety will be monitored by a physician and nurse. 18F-florbetapir will be administered to you as a bolus injection through a peripheral vein followed by a flush and 10 minute continuous brain PET imaging will begin 50 minutes post-injection.
DEVICERadioligand 18F-AV-1451
At the Duke University PET Center you will be in a quiet dimly lit space with only ambient room sound, with your eyes open and ears unplugged. Your safety will be monitored by a physician and nurse. 18F-florbetapir will be administered to you as a bolus injection through a peripheral vein followed by a flush and 10 minute continuous brain PET imaging will begin 50 minutes post-injection.
Sponsors
Duke University
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Age 18 to 65 * Previously enrolled in studies of OEF/OIF veterans by the same investigators * Free of implanted metal objects or mental shards in eyes * Fluent in English and capable of consenting
Exclusion criteria
* Axis I disorders other than Major Depressive Disorder or PTSD * Current substance abuse or lifetime substance dependence (other than nicotine) * High risk for suicide * Claustrophobia * Neurological disorders * Learning disability or developmental delay * Major medical conditions
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cortical thickness as measured by MRI scans | Baseline |
| Beta amyloid plaques as measured by PET scans | Baseline |
| Tau proteins as measured by PET scans | Baseline |
Countries
United States
Outcome results
None listed