Postoperative Pain
Conditions
Brief summary
The aim of this work is to compare the hemodynamic and analgesic properties of Dexmedetomidine and Magnesium sulphate infusion in lower abdominal surgery.
Detailed description
Dexmedetomidine is a relatively new alpha 2 adrenergic receptor agonist with a higher α2/α1 selectivity ratio of 1620:1 that provides analgesic and anesthetic effects . Dexmedetomidine has various clinical uses in anesthesia such as sedation, and prolongation of the duration of postoperative analgesia when used as an adjuvant through intrathecal, epidural, or intravenous routes. Magnesium sulphate is another commonly used drug in anesthesia. Magnesium sulphate suppresses nociceptive impulses through inhibition of voltage-gated calcium channels and through antagonism of the N-methyl D-aspartate (NMDA) receptors. Although both drugs were reported to prolong the duration of spinal anesthesia, no studies to the best of our knowledge had compared the analgesic and hemodynamic profile of both drugs when used as intravenously during spinal anesthesia.
Interventions
DRUGDexmedetomidine
This group will receive Dexmedetomidine infusion at a rate of 0.5 mcg/kg/hour.
DRUGMagnesium Sulphate
This group will receive Magnesium sulphate infusion at a rate of 15 mg/Kg/hour
DRUGNormal saline
This group will receive normal saline infusion
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Adult patients aged between 18 and 65 years. * Scheduled for lower abdominal surgery.
Exclusion criteria
* Systolic blood pressure less than 100 mmHg * Coagulation disorders * History of heart failure * Mitral or Aortic stenosis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Duration of analgesia | 24 hours | Duration of analgesia after the operation defined as the time till the first analgesic request by the patient |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Diastolic blood pressure | 6 hours | Diastolic blood pressure measured in mmHg |
| Heart rate | 6 hours | The number of heart beats per minute |
| Onset of sensory block | 30 minutes after spinal anesthesia | The time needed to have complete sensory block after spinal anesthesia measured in minutes |
| Systolic blood pressure | 6 hours | Systolic blood pressure measured in mmHg |
| Duration of motor block | 12 hours | The time needed for recovery of motor motor after spinal anesthesia measured in hours |
| Ramsay Sedation Scale | 12 hours after spinal anesthesia | A scale used for assessment of sedation level ranges from 1 (combative) to 6 (unarousable) |
| Onset of motor block | 30 minutes after spinal anesthesia | The time needed to have complete motor block after spinal anesthesia measured in minutes |
Countries
Egypt
Outcome results
None listed