Evaluation of The Effect of Live Probiotic Cultures Present in Fermented Dairy Product (Yogurt) Versus The Effect of Freeze-Dried Probiotic Sachets on Gingival Bleeding of Adolescents

The Effect of Freeze-Dried Probiotic Sachets Versus Fermented Dairy Product (Yogurt) on Gingival Bleeding on Brushing in Adolescents (12-15) Years Old : A Randomized Clinical Pilot Study

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03640065

Enrollment

Registered

2018-08-21

Start date

2019-10-20

Completion date

2020-03-31

Last updated

2020-12-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gingival Inflammation

Brief summary

To evaluate the effect of probiotics supplied in two different forms (dairy products containing probiotics as yogurt and freeze-dried synthetic probiotics sachets) on improving gingival condition and caries potentiality of dental plaque in adolescents

Interventions

DRUGfreeze-dried probiotic sachets

* The participants will be instructed to consume the sachets as follow, each sachet powder is mixed with 10 ml of water in a measuring cup, then swish the mixture in the mouth for one minute before swallowing. * This procedure will be repeated once daily for the following 4 weeks. * 4 weeks supply will be given to the participants.

DIETARY_SUPPLEMENTfermented dairy product ( yogurt)

* The participants will be instructed to consume the yogurt once daily regularly for the following 4 weeks. * 4 weeks supply will be given to the participants with instruction to store the yogurt in refrigerator at home

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Masking description

only statistician was blind known participants only by codes

Eligibility

Sex/Gender

ALL

Age

12 Years to 15 Years

Healthy volunteers

Yes

Inclusion criteria

1. Children aged 12-15 years old 2. Children complaining from gingival problems 3. Medically free children 4. Children not registered in other clinical researches

Exclusion criteria

1. Children with systemic diseases, mental disorders, chronic debilitating diseases. 2. Children using antibiotic treatment during the study 3. Children with orthodontic treatment 4. Children using antimicrobial mouthwash 5. Children taking any probiotic supplemental therapy

Design outcomes

Primary

Measure	Time frame	Description
Change in Gingival bleeding On Brushing	base line and after 4 weeks	Patient questioning and answering with yes or no on a questionnaire

Secondary

Measure	Time frame	Description
Change in Dental plaque pH	base line and after 4 weeks	Pooled plaque sample (pH meter) on scale (1-14)

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026