Chronic Cough
Conditions
Keywords
cough, cough provocation test, mannitol, citric acid
Brief summary
Comparison of citric acid and mannitol cough provocation tests among subjects with chronic cough and healthy volunteers.
Detailed description
35 subjects with chronic cough plus 25 subjects without any cough will be asked to participate. The study consists of two visits in the outpatient clinic of Kuopio University Hospital, department of respiratory medicine, 2 - 7 days apart. They will fill in the Leicester Cough Questionnaire and undergo two different cough provocation tests, in random order: Mannitol test and citric acid test. If a chest x-ray has not been taken within 6 months, it will be taken.
Interventions
DIAGNOSTIC_TESTCitric acid aerosol bronchial challenge
Inhalation challenge by citric acid aerosol to investigate the subject's cough sensitivity
DIAGNOSTIC_TESTMannitol aerosol bronchial challenge
Inhalation challenge by mannitol aerosol to investigate the subject's cough sensitivity
Sponsors
University of Helsinki
Kuopio University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Intervention model description
This study compares citric acid and mannitol bronchial challenges in their ability to separate chronic cough subjects from healthy subjects. There are no therapeutic interventions.
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
, Chronic cough patients: (both criteria must be fulfilled) * presence of current chronic cough (\> 8 weeks) * Leicester Cough Questionnaire total score \< 17 Inclusion criteria, healthy volunteers * absence of any form of cough
Exclusion criteria
* age \< 18 years * any disability which would challenge the subject's ability to understand the purpose and methods of the study * pregnancy * breastfeeding * current smoking or ex smoking more than 10 pack years * any thoracic x-ray finding indicating urgent mediacal interventions
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Receiver operator characteristic curves of the citric acid and the mannitol aerosol bronchial challenges | Within one week from the start of the study in each individual | Receiver operator characteristic curve describes the ability of the bronchial challenge to separate the cough patients from healthy volunteers |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Leicester Cough Questionnaire total score | The first study day | Measures cough-spesific quality of life. Range is 3 - 21 with low total score indicating poor cough-spesific quality of life. The three Leicester Cough Questionnaire subscales are added together to form the total score. |
Countries
Finland
Outcome results
None listed