Innate Immunity, Periodontal Health
Conditions
Keywords
Children, Cotinine, LL-37, Passive smoking, Periodontal health, Saliva
Brief summary
This study investigates the salivary LL-37 in passive smoking-exposed and unexposed children and the association between salivary LL-37 levels and periodontal clinical parameters in these children.Unstimulated salivary samples were collected from 180 children (90 passive smoking-exposed and 90 passive smoking-unexposed)
Detailed description
Diverse mechanisms conduce to the detrimental periodontal effects of passive smoking, including alteration of both microbial and host response factors. Antimicrobial peptides are considered to be an important intermediate step in initiating an initial immune response against the microbial side of the oral gingival epithelium and in the transition to acquired immunity. LL-37 has a wide antimicrobial activity against both cariogenic and periopathogenic bacteria and its role in maintaining oral health has recently been stated
Interventions
None listed
Sponsors
Kırıkkale University
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
6 Years to 12 Years
Healthy volunteers
Yes
Inclusion criteria
* Systemically healthy children
Exclusion criteria
* Any medications known to affect defense system and periodontium * The presence of orthodontic / intraoral appliance
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Antimicrobial Peptide | In the first 18 months of study | LL-37 (pg/mL) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Passive smoking measurement | In the first 18 months of study | Cotinine (ng/mL) |
Outcome results
None listed