Alzheimer Prevention Trials (APT) Webstudy

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03638583

Enrollment

200000

Registered

2018-08-20

Start date

2017-12-20

Completion date

2026-04-30

Last updated

2025-07-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alzheimer Disease, Dementia

Keywords

Alzheimer's, Prevention, Web-Based

Brief summary

The goal of the Alzheimer Prevention Trials (APT) Webstudy is to accelerate enrollment for Alzheimer's disease (AD) clinical trials by identifying and tracking individuals who may be at higher risk for developing AD dementia.

Detailed description

The APT Webstudy will use web-based cognitive testing and questionnaires to generate a risk score which will be used to identify individuals who may be at an increased risk for developing AD dementia. Individuals who join the APT Webstudy will register at https://www.aptwebstudy.org/, sign an electronic informed consent form (ICF), provide basic demographic information and participate in web-based cognitive testing. Participants will return the APT Webstudy quarterly (every 3 months) to complete the cognitive testing again. Based on the risk score and changes identified in the cognitive testing results, participants will be invited to visit a partnering clinical trial site for an in-person visit with biomarker testing and clinical assessment. The combined results of the web-based assessments, with the biomarker and clinical assessments, will allow an adaptive statistical algorithm to improve the selection of those at highest risk for developing AD. To Join the APT Webstudy, please visit https://www.aptwebstudy.org/.

Interventions

None listed

Study design

Observational model

OTHER

Time perspective

OTHER

Eligibility

Sex/Gender

ALL

Age

50 Years to 85 Years

Healthy volunteers

Yes

Inclusion criteria

* male or female at least 50 years of age * no evidence of dementia * willing to participate in remote longitudinal cognitive testing and possible referral for biomarker assessment based on risk

Exclusion criteria

* N/A. Anyone can register for the APT Webstudy, however, only individuals identified using the risk algorithm will be referred for in-person biomarker assessments.

Design outcomes

Primary

Measure	Time frame
Enrollment into Alzheimer's prevention research studies	5 years

Secondary

Measure	Time frame
Referral into prevention research studies	5 years
Number of individuals enrolled into Alzheimer's prevention studies	5 years

Countries

United States

Contacts

Primary ContactAPT Webstudy Team

info@aptwebstudy.org858-877-3135

Outcome results