Alzheimer Disease, Lexical Syntactic Disorder, Presbycusis
Conditions
Brief summary
In France, Alzheimer's disease accounts for 70 to 80% of the causes of neurocognitive disorders, i.e. 600,000 to 800,000 patients. It is a neurodegenerative pathology that causes evolutionary cognitive dysfunction, mainly affecting memory functions. The inability to name familiar objects (lack of the word) is one of the most commonly noted symptoms at an early stage of the disease. Presbyacusis, or age-related hearing loss, is the most common sensory deficit in the elderly which is manifested socially by a progressive discomfort of verbal communication. Presbyacusis remains underdiagnosed and undertreated: 2/3 of the patients are not using hearing aid. In recent years, a link between neurocognitive disorders and hearing loss has been shown by investigating general cognition. In this study, the investigators are investigating lexical disorders.
Interventions
OTHERSpeech therapy
During a 1-hour speech-language consultation, a lack of word evaluation will be conducted and patient will answer a Hearing Difficulty Questionnaire
Sponsors
Groupe Hospitalier de la Rochelle Ré Aunis
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* \> 65 years old * French mother tongue * Good vision with or without correction * Alzheimer's or related disease (15 \<Mini-Mental State Examination\<25) * Affiliate or beneficiary of a social security * Informed consent
Exclusion criteria
* Cognitive disorders related to another pathology (cerebrovascular accident, head trauma, epilepsy ...) * Protected patient (under guardianship) or person deprived of liberty by judicial or administrative decision
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Link Between Lack of Word and Presbycusis | at inclusion | The Batterie Informatisée du Manque du Mot (BIMM) is a computerized assessment instrument for denominational disorders. It provides information on level of lexical impairment, type of error (phonological, semantic, visual perceptual) and response time. It comprises two tests: denomination of nouns (42 items, score range from 0 to 42) and of verbs (28 items, score range from 0 to 28). The results are presented in a report including scores, description of qualitative errors, and results per item. A global score of less than 40 indicates a lack of words. The score range is between 0 and 70. The hearing questionnaire consists in 14 questions about concrete situations and a direct question about what the patient thinks of his hearing. Answers are quoted 0, 2 or 4 points. An overall score greater than 14 indicates presbycusis. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Association Between Age and Lack of Word | at inclusion | Age of patients and score at the lack of word questionnaire (BIMM) The Batterie Informatisée du Manque du Mot (BIMM) is a computerized assessment instrument for denominational disorders. It provides information on level of lexical impairment, type of error (phonological, semantic, visual perceptual) and response time. It comprises two tests: denomination of nouns (42 items) and of verbs (28 items). The results are presented in a report including scores, description of qualitative errors, and results per item. An score less than 40 indicates lack of word. |
| Association Between Gender and Lack of Word | at inclusion | Male or female and score at the lack of word questionnaire (BIMM) The Batterie Informatisée du Manque du Mot (BIMM) is a computerized assessment instrument for denominational disorders. It provides information on level of lexical impairment, type of error (phonological, semantic, visual perceptual) and response time. It comprises two tests: denomination of nouns (42 items) and of verbs (28 items). The results are presented in a report including scores, description of qualitative errors, and results per item. An score less than 40 indicates lack of word. |
| Association Between Study Level and Lack of Word | at inclusion | Primary (certificate study), secondary and tertiary study (baccalaureat and more) level and score at the lack of word questionnaire (BIMM) The Batterie Informatisée du Manque du Mot (BIMM) is a computerized assessment instrument for denominational disorders. It provides information on level of lexical impairment, type of error (phonological, semantic, visual perceptual) and response time. It comprises two tests: denomination of nouns (42 items) and of verbs (28 items). The results are presented in a report including scores, description of qualitative errors, and results per item. An score less than 40 indicates lack of word. |
| Association Between Accommodation Type and Lack of Word | at inclusion | Patient living at home or in an institution and score at the lack of word questionnaire (BIMM) The Batterie Informatisée du Manque du Mot (BIMM) is a computerized assessment instrument for denominational disorders. It provides information on level of lexical impairment, type of error (phonological, semantic, visual perceptual) and response time. It comprises two tests: denomination of nouns (42 items) and of verbs (28 items). The results are presented in a report including scores, description of qualitative errors, and results per item. An score less than 40 indicates lack of word. |
| Association Between Laterality and Lack of Word | at inclusion | Right or left handed patients and score at the lack of word questionnaire (BIMM) The Batterie Informatisée du Manque du Mot (BIMM) is a computerized assessment instrument for denominational disorders. It provides information on level of lexical impairment, type of error (phonological, semantic, visual perceptual) and response time. It comprises two tests: denomination of nouns (42 items) and of verbs (28 items). The results are presented in a report including scores, description of qualitative errors, and results per item. An score less than 40 indicates lack of word. |
| Association Between Main Diagnosis and Lack of Word | at inclusion | Alzheimer's disease or related disease and score at the lack of word questionnaire (BIMM) The Batterie Informatisée du Manque du Mot (BIMM) is a computerized assessment instrument for denominational disorders. It provides information on level of lexical impairment, type of error (phonological, semantic, visual perceptual) and response time. It comprises two tests: denomination of nouns (42 items) and of verbs (28 items). The results are presented in a report including scores, description of qualitative errors, and results per item. An score less than 40 indicates lack of word. |
| Association Between Hearing Aid and Lack of Word | at inclusion | Patients with or without hearing aid and score at the lack of word questionnaire (BIMM) The Batterie Informatisée du Manque du Mot (BIMM) is a computerized assessment instrument for denominational disorders. It provides information on level of lexical impairment, type of error (phonological, semantic, visual perceptual) and response time. It comprises two tests: denomination of nouns (42 items) and of verbs (28 items). The results are presented in a report including scores, description of qualitative errors, and results per item. An score less than 40 indicates lack of word. |
| Association Between Speech Therapy and Lack of Word | at inclusion | Patients with or without ongoing speech therapy and score at the lack of word questionnaire (BIMM) The Batterie Informatisée du Manque du Mot (BIMM) is a computerized assessment instrument for denominational disorders. It provides information on level of lexical impairment, type of error (phonological, semantic, visual perceptual) and response time. It comprises two tests: denomination of nouns (42 items) and of verbs (28 items). The results are presented in a report including scores, description of qualitative errors, and results per item. An score less than 40 indicates lack of word. |
Countries
France
Contacts
STUDY_DIRECTORMarie-Laure Vignaud, Ph.D.
Groupe Hospitalier de la Rochelle Ré Aunis
Participant flow
Pre-assignment details
Number of screend patients: 46 Number of patient excluded: 9 * 1 refusal * 7 lack an inclusion criteria or had an exclusion criteria * 1 was excluded after enrolment due to comprehension disorders and unreliable responses to the Hearing Questionnaire
Participants by arm
| Arm | Count |
|---|---|
| Normal Hearing Participants were divided into two groups based on their score on the Hearing Questionnaire. Patients with a score of less than 14 are in the normal hearing group | 29 |
| Risk of Presbycusis Participants were divided into two groups based on their score on the Hearing Questionnaire. Patients with a score of 14 or more are in the risk of presbycusis group | 8 |
| Total | 37 |
Baseline characteristics
| Characteristic | Total | Normal Hearing | Risk of Presbycusis |
|---|---|---|---|
| Age, Continuous | 79 years | 78 years | 80.5 years |
| Diagnostic Alzheimer's disease | 10 Participants | 7 Participants | 3 Participants |
| Diagnostic Related disease | 27 Participants | 22 Participants | 5 Participants |
| Educational level baccalaureat or more | 14 Participants | 11 Participants | 3 Participants |
| Educational level Certificate study | 23 Participants | 18 Participants | 5 Participants |
| Hearing aid no | 34 Participants | 28 Participants | 6 Participants |
| Hearing aid yes | 3 Participants | 1 Participants | 2 Participants |
| Laterality left handed | 3 Participants | 3 Participants | 0 Participants |
| Laterality right handed | 34 Participants | 26 Participants | 8 Participants |
| Race and Ethnicity Not Collected | 0 Participants | — | — |
| Residency At home | 36 Participants | 29 Participants | 7 Participants |
| Residency Institution | 1 Participants | 0 Participants | 1 Participants |
| Sex: Female, Male Female | 25 Participants | 19 Participants | 6 Participants |
| Sex: Female, Male Male | 12 Participants | 10 Participants | 2 Participants |
| Speech and language therapy no | 27 Participants | 23 Participants | 4 Participants |
| Speech and language therapy yes | 10 Participants | 6 Participants | 4 Participants |
Adverse events
| Event type | EG000 affected / at risk |
|---|---|
| deaths Total, all-cause mortality | 0 / 37 |
| other Total, other adverse events | 0 / 37 |
| serious Total, serious adverse events | 0 / 37 |
Outcome results
Primary
Link Between Lack of Word and Presbycusis
The Batterie Informatisée du Manque du Mot (BIMM) is a computerized assessment instrument for denominational disorders. It provides information on level of lexical impairment, type of error (phonological, semantic, visual perceptual) and response time. It comprises two tests: denomination of nouns (42 items, score range from 0 to 42) and of verbs (28 items, score range from 0 to 28). The results are presented in a report including scores, description of qualitative errors, and results per item. A global score of less than 40 indicates a lack of words. The score range is between 0 and 70. The hearing questionnaire consists in 14 questions about concrete situations and a direct question about what the patient thinks of his hearing. Answers are quoted 0, 2 or 4 points. An overall score greater than 14 indicates presbycusis.
Time frame: at inclusion
| Arm | Measure | Group | Value (MEDIAN) |
|---|---|---|---|
| Normal Hearing | Link Between Lack of Word and Presbycusis | Global score | 38 score on a scale |
| Normal Hearing | Link Between Lack of Word and Presbycusis | Score at denomination of nouns | 23 score on a scale |
| Normal Hearing | Link Between Lack of Word and Presbycusis | Score at denomination of verbs | 15 score on a scale |
| Risk of Presbycusis | Link Between Lack of Word and Presbycusis | Global score | 38.5 score on a scale |
| Risk of Presbycusis | Link Between Lack of Word and Presbycusis | Score at denomination of nouns | 21.5 score on a scale |
| Risk of Presbycusis | Link Between Lack of Word and Presbycusis | Score at denomination of verbs | 17 score on a scale |
Secondary
Association Between Accommodation Type and Lack of Word
Patient living at home or in an institution and score at the lack of word questionnaire (BIMM) The Batterie Informatisée du Manque du Mot (BIMM) is a computerized assessment instrument for denominational disorders. It provides information on level of lexical impairment, type of error (phonological, semantic, visual perceptual) and response time. It comprises two tests: denomination of nouns (42 items) and of verbs (28 items). The results are presented in a report including scores, description of qualitative errors, and results per item. An score less than 40 indicates lack of word.
Time frame: at inclusion
| Arm | Measure | Category | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|---|
| Normal Hearing | Association Between Accommodation Type and Lack of Word | At home | 15 Participants |
| Normal Hearing | Association Between Accommodation Type and Lack of Word | Institution | 1 Participants |
| Risk of Presbycusis | Association Between Accommodation Type and Lack of Word | At home | 21 Participants |
| Risk of Presbycusis | Association Between Accommodation Type and Lack of Word | Institution | 0 Participants |
Secondary
Association Between Age and Lack of Word
Age of patients and score at the lack of word questionnaire (BIMM) The Batterie Informatisée du Manque du Mot (BIMM) is a computerized assessment instrument for denominational disorders. It provides information on level of lexical impairment, type of error (phonological, semantic, visual perceptual) and response time. It comprises two tests: denomination of nouns (42 items) and of verbs (28 items). The results are presented in a report including scores, description of qualitative errors, and results per item. An score less than 40 indicates lack of word.
Time frame: at inclusion
| Arm | Measure | Value (MEDIAN) |
|---|---|---|
| Normal Hearing | Association Between Age and Lack of Word | 76 years |
| Risk of Presbycusis | Association Between Age and Lack of Word | 80 years |
Secondary
Association Between Gender and Lack of Word
Male or female and score at the lack of word questionnaire (BIMM) The Batterie Informatisée du Manque du Mot (BIMM) is a computerized assessment instrument for denominational disorders. It provides information on level of lexical impairment, type of error (phonological, semantic, visual perceptual) and response time. It comprises two tests: denomination of nouns (42 items) and of verbs (28 items). The results are presented in a report including scores, description of qualitative errors, and results per item. An score less than 40 indicates lack of word.
Time frame: at inclusion
| Arm | Measure | Category | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|---|
| Normal Hearing | Association Between Gender and Lack of Word | Female | 7 Participants |
| Normal Hearing | Association Between Gender and Lack of Word | Male | 9 Participants |
| Risk of Presbycusis | Association Between Gender and Lack of Word | Female | 18 Participants |
| Risk of Presbycusis | Association Between Gender and Lack of Word | Male | 3 Participants |
Secondary
Association Between Hearing Aid and Lack of Word
Patients with or without hearing aid and score at the lack of word questionnaire (BIMM) The Batterie Informatisée du Manque du Mot (BIMM) is a computerized assessment instrument for denominational disorders. It provides information on level of lexical impairment, type of error (phonological, semantic, visual perceptual) and response time. It comprises two tests: denomination of nouns (42 items) and of verbs (28 items). The results are presented in a report including scores, description of qualitative errors, and results per item. An score less than 40 indicates lack of word.
Time frame: at inclusion
| Arm | Measure | Category | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|---|
| Normal Hearing | Association Between Hearing Aid and Lack of Word | yes | 0 Participants |
| Normal Hearing | Association Between Hearing Aid and Lack of Word | no | 16 Participants |
| Risk of Presbycusis | Association Between Hearing Aid and Lack of Word | yes | 3 Participants |
| Risk of Presbycusis | Association Between Hearing Aid and Lack of Word | no | 18 Participants |
Secondary
Association Between Laterality and Lack of Word
Right or left handed patients and score at the lack of word questionnaire (BIMM) The Batterie Informatisée du Manque du Mot (BIMM) is a computerized assessment instrument for denominational disorders. It provides information on level of lexical impairment, type of error (phonological, semantic, visual perceptual) and response time. It comprises two tests: denomination of nouns (42 items) and of verbs (28 items). The results are presented in a report including scores, description of qualitative errors, and results per item. An score less than 40 indicates lack of word.
Time frame: at inclusion
| Arm | Measure | Category | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|---|
| Normal Hearing | Association Between Laterality and Lack of Word | Right handed | 16 Participants |
| Normal Hearing | Association Between Laterality and Lack of Word | Left handed | 0 Participants |
| Risk of Presbycusis | Association Between Laterality and Lack of Word | Right handed | 18 Participants |
| Risk of Presbycusis | Association Between Laterality and Lack of Word | Left handed | 3 Participants |
Secondary
Association Between Main Diagnosis and Lack of Word
Alzheimer's disease or related disease and score at the lack of word questionnaire (BIMM) The Batterie Informatisée du Manque du Mot (BIMM) is a computerized assessment instrument for denominational disorders. It provides information on level of lexical impairment, type of error (phonological, semantic, visual perceptual) and response time. It comprises two tests: denomination of nouns (42 items) and of verbs (28 items). The results are presented in a report including scores, description of qualitative errors, and results per item. An score less than 40 indicates lack of word.
Time frame: at inclusion
| Arm | Measure | Category | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|---|
| Normal Hearing | Association Between Main Diagnosis and Lack of Word | Alzheimer's disease | 3 Participants |
| Normal Hearing | Association Between Main Diagnosis and Lack of Word | Related disease | 13 Participants |
| Risk of Presbycusis | Association Between Main Diagnosis and Lack of Word | Alzheimer's disease | 7 Participants |
| Risk of Presbycusis | Association Between Main Diagnosis and Lack of Word | Related disease | 14 Participants |
Secondary
Association Between Speech Therapy and Lack of Word
Patients with or without ongoing speech therapy and score at the lack of word questionnaire (BIMM) The Batterie Informatisée du Manque du Mot (BIMM) is a computerized assessment instrument for denominational disorders. It provides information on level of lexical impairment, type of error (phonological, semantic, visual perceptual) and response time. It comprises two tests: denomination of nouns (42 items) and of verbs (28 items). The results are presented in a report including scores, description of qualitative errors, and results per item. An score less than 40 indicates lack of word.
Time frame: at inclusion
| Arm | Measure | Category | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|---|
| Normal Hearing | Association Between Speech Therapy and Lack of Word | yes | 5 Participants |
| Normal Hearing | Association Between Speech Therapy and Lack of Word | no | 11 Participants |
| Risk of Presbycusis | Association Between Speech Therapy and Lack of Word | yes | 5 Participants |
| Risk of Presbycusis | Association Between Speech Therapy and Lack of Word | no | 16 Participants |
Secondary
Association Between Study Level and Lack of Word
Primary (certificate study), secondary and tertiary study (baccalaureat and more) level and score at the lack of word questionnaire (BIMM) The Batterie Informatisée du Manque du Mot (BIMM) is a computerized assessment instrument for denominational disorders. It provides information on level of lexical impairment, type of error (phonological, semantic, visual perceptual) and response time. It comprises two tests: denomination of nouns (42 items) and of verbs (28 items). The results are presented in a report including scores, description of qualitative errors, and results per item. An score less than 40 indicates lack of word.
Time frame: at inclusion
| Arm | Measure | Category | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|---|
| Normal Hearing | Association Between Study Level and Lack of Word | Primary level | 6 Participants |
| Normal Hearing | Association Between Study Level and Lack of Word | Secondary & tertiary level | 10 Participants |
| Risk of Presbycusis | Association Between Study Level and Lack of Word | Primary level | 17 Participants |
| Risk of Presbycusis | Association Between Study Level and Lack of Word | Secondary & tertiary level | 4 Participants |