Vestibular Function Disorder, Vestibular Schwannoma
Conditions
Brief summary
The aim of this study is to assess effect of psychiatric profile on visual sensitivity and overall health status in patients who underwent surgery for vestibular schwannoma and were prehabituated by chemical vestibular ablation.
Interventions
PROCEDUREintratympanic application of gentamicin
under local anesthesia is gentamicin instilled through tympanic membrane to tympanic cavity
PROCEDUREmicrosurgical removal of vestibular schwannoma
surgery under general anesthesia
Sponsors
Charles University, Czech Republic
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
two groups of patients, one group prehabituated by chemical labyrintectomy, the second control group without prehabituation before the surgery
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* T3, T4 vestibular schwannoma * recorded growth of a tumour * hearing loss greater than 50% in PTA
Exclusion criteria
* T1 vestibular schwannomas * no growth progression * normal hearing
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| change of optokinetic nystagmus measurement | change of the gain of optokinetic nystagmus among 3 time points is measured: before intervention, 1 week after intervention, 3 months after intervention | During electronystagmography gain of optokinetic nystagmus is measured before and after the intervention |
Countries
Czechia
Outcome results
None listed