Nutritional Care and Head Growth in Preterm Infants

Nutritional Care Influences Head Growth at Discharge in Extremely Low Birth Weight Infants.

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03635944

Acronym

KARLY

Enrollment

Registered

2018-08-17

Start date

2016-12-01

Completion date

2018-07-01

Last updated

2018-08-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Growth Retardation, Prematurity; Extreme

Keywords

growth, small for gestational age, prematurity, breastfeeding, fortification, parenteral nutrition, nutrition

Brief summary

As extremely low birth weight infants are high-risk patients, the study aimed to compare neonatal care, nutritional strategy and postnatal growth of these infants in two European neonatal units. A retrospective study included extremely low birth weight infants born in Lyon, France or in Stockholm, Sweden. Data on morbidity, treatments, care practices, macro-nutrient intakes and postnatal growth were collected to determine risk factors of extra uterine growth restriction at discharge. By comparing postnatal growth in ELBW infants hospitalized in two European neonatal intensive care units with different nutritional and extra nutritional care,our objective was to evaluate the role of nutrition in this population of preterm infants.

Detailed description

In a retrospective study, all ELBW infants (birth weight under 1000 g) with a gestational age between 23 and 28 weeks were included if they were admitted during the first 24 hours of life and stayed for at least seven weeks in two European units (Lyon, france, and Stockholm, Sweden). Parenteral and enteral nutrition policies were detailed and protein and energy intakes were collected.Growth assessment Postnatal growth was precisely evaluated and compared in the two groups of infants. Body weight, crown-heel length and head circumference were measured in both units at birth and until discharge. We calculated z-scores and changes in z-scores between birth and 36 weeks post-conceptional age (delta z-score) for body weight, HC, and crown-to-heel length using Olsen's references. Intra-uterine growth restriction was defined as a birth weight below or equal to minus two standard deviations. Extra-uterine growth restriction was defined as a z-score loss above or equal one standard deviation between birth and 36 weeks PCA. I

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

1 Minutes to 6 Months

Healthy volunteers

Inclusion criteria

* birth weight under 1000 grams * gestational age (GA) between 23 and 28 weeks * born in 2012 * admitted during the first 24 hours of life * stayed in one of the two studied units for at least 7 weeks before transfer to the referring hospital, discharge to home or death.

Exclusion criteria

* Neonates with congenital anomalies

Design outcomes

Primary

Measure	Time frame	Description
Weight gain during hospitalization	between birth and 40 weeks	difference in weight between birth and discharge

Secondary

Measure	Time frame	Description
Crown-heel length gain during hospitalization	between birth and 40 weeks	difference in recumbent length between birth and discharge
Head circumference gain during hospitalization	between birth and 40 weeks	difference in head circumference between birth and discharge

Countries

France

Outcome results