Diabetic Retinopathy
Conditions
Keywords
Imaging, Diabetes, OCTA
Brief summary
The prevalence of diabetes mellitus (DM) is increasing worldwide. Diabetic retinopathy is the most prevalent complication of DM and a leading cause of visual impairment. Some factors are known to temporarily aggravate or improve diabetic retinopathy, but underlying pathophysiologic factors are still unknown. High-resolution imaging techniques of the retina and its supplying vascular networks now allow novel insight to subtle changes that cannot be appreciated in standard fundus examination. In detail, the investigators image study patients with optical coherence tomography (OCT) - technology, that provides morphological information of retinal structure and the supplying vessels in a non-invasive way. Retinal layer thickness as well as capillary density will be quantified and followed in patients that are in a critical period of disease transition to better understand the process of diabetic retinopathy.
Interventions
DIAGNOSTIC_TESTOptical Coherence Tomography Angiography
Retinal scans will be acquired at each follow up visit
Sponsors
University of British Columbia
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* Diabetes mellitus type 1 or 2 * Age 18-90
Exclusion criteria
* Media opacities like cataract or vitreous hemorrhage * Active intraocular inflammation (grade trace or above) in either eye like infectious conjunctivitis, keratitis, scleritis, endophthalmitis as well as idiopathic or autoimmune-associated uveitis in either eye * Structural damage to the center of macula in the study eye * Atrophy of retinal pigment epithelium, subretinal fibrosis, laser scar within foveal avascular zone (FAZ) or organized hard exudate plaques * Ocular disorders in the study eye including retinal vascular occlusion, retinal detachment, macular hole, choroidal neovascularization, macula dystrophies * Intraocular surgery (including cataract surgery, YAG laser capsulotomy) in the study eye within 3 months preceding Day 0, or history of corneal transplantation in the study eye * Uncontrolled glaucoma in the study eye (defined as intraocular pressure ≥ 25 mmHg despite treatment with anti-glaucoma medication)or history of glaucoma filtration surgery * Inability to obtain fundus photographs or fluorescein angiograms of sufficient quality to be analyzed and graded
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Perfusion density | 6 months | Mean change of perfusion density of the macula evaluated within the 9 ETDRS subfields for the superior and inferior vascular plexus separately. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Perfusion density | 12 months | Mean change of perfusion density of the macula evaluated within the 9 ETDRS subfields for the superior and inferior vascular plexus separately. |
| Retinal layer thickness | 6 and 12 months | Mean change in retinal layer thickness of all retinal layers separately |
Countries
Canada
Outcome results
None listed