Risk Factor of POD and POCD After Cardiac Surgery

Risk Factor of Postoperative Delirium and Postoperative Cognitive Decline After Cardiac Surgery

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03635229

Enrollment

360

Registered

2018-08-17

Start date

2018-08-21

Completion date

2023-12-31

Last updated

2023-10-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative Cognitive Dysfunction, Postoperative Delirium

Keywords

cardiac surgery, perioperative care, postoperative delirium, postoperative cognitive dysfunction

Brief summary

Postoperative delirium (POD) and postoperative cognitive decline (POCD) are common after surgeries in the elderly, especially after cardiothoracic surgery. These conditions are associated with adverse short- and long-term outcomes. Multiple conditions in the perioperative period have been proposed as risk factors of POD and POCD. Incidences vary across institutions due to differences in screening and diagnostic tools.

Detailed description

This is a prospective observational study to identify the incidences and risk factors of postoperative delirium and postoperative cognitive decline after elderly patients undergoing cardiac surgical procedures which require cardiopulmonary bypass and postoperative intensive care unit (ICU) admission. Patients will be screen for POD and POCD with various psychological tests in the postoperative period and after hospital discharge. Perioperative data and outcomes will be used to identify risk factors of both conditions.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

60 Years to No maximum

Healthy volunteers

Inclusion criteria

* age 65 years old or older * undergoing open heart surgery (cardiopulmonary bypass assisted cardiothoracic surgery

Exclusion criteria

* unable to communicate * severe visual or hearing impairment

Design outcomes

Primary

Measure	Time frame	Description
Postoperative delirium	Postoperative day 1-5 (5 consecutive days)	A result consistent with postoperative delirium by using Confusion Assessment Method-ICU (CAM-ICU) in the postoperative period

Secondary

Measure	Time frame	Description
Postoperative cognitive dysfunction - postoperative	Postoperative day 5-9 (5 consecutive days)	A result consistent with postoperative cognitive dysfunction by using Montreal Cognitive Assessment (MOCA)
Postoperative cognitive dysfunction - 3 month	At 3rd month after hospital discharge	A result consistent with postoperative cognitive dysfunction by using Montreal Cognitive Assessment (MOCA)
Postoperative cognitive dysfunction - 1 year	At 12th month after hospital discharge	A result consistent with postoperative cognitive dysfunction by using Montreal Cognitive Assessment (MOCA)

Countries

Thailand

Outcome results