Acute Pancreatitis
Conditions
Keywords
Heat Shock Proteins, early diagnosis
Brief summary
To investigate the role of Heat Shock Proteins in the mechanism of acute severe pancreatitis. In addition to test the potential treatment target of acute pancreatitis. All patients who present with clinical symptoms of acute pancreatitis are evaluated for the enrollment of the study.
Detailed description
All patients with acute pancreatitis are evaluated according to modified Atlanta classification acute pancreatitis severity scores. Blood serum, urine and DNA samples are collected from all patients presented on admission, after 24 hours, 48 hours, 72 hours. CT is performed in al patients to evaluate necrosis of pancreas Day 5-7 since hospital admission. If necrosis is not present follow-up is stopped.
Interventions
DIAGNOSTIC_TESTCT Scan Day 5-7
Computed Tomography on Day 5-7 according to a clinical protocol.
Sponsors
Vilnius University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 100 Years
Inclusion criteria
* no prior diagnosis of acute pancreatitis * admission to the hospital within 2 days since the clinical symptoms * confirmed diagnosis of acute pancreatitis
Exclusion criteria
* chronic pancreatitis * pancreatic cancer
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| To measure the levels of heat shock proteins in serum and plasma in acute severe pancreatitis settings | 2 years | Different molecular weight Heat Shock proteins role while developing acute pancreatitis. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| To measure pancreas cells activity while applying Heat Shock Protein inhibitors | 2 years | To establish a mechanism explaining the potential use of heat shock proteins inhibitors/ activators for treatment of acute pancreatitis |
Countries
Lithuania
Contacts
Primary ContactKestutis Strupas, Prof. MD/PhD
Backup ContactAiste Gulla, MD
Outcome results
None listed