Brain-injured Patients on Extracorporeal Life Support
Conditions
Brief summary
It seems of the greatest importance to evaluate the neurological prognosis of patients with brain lesions after cardiorespiratory arrest or circulatory failure requiring circulatory assistance. However, to date, there is no clinical or paraclinical diagnostic test to reliably assess the future of these patients. The objective of this study is to highlight the clinical and imaging factors for establishing a neurological prognosis in patients at risk of brain lesions under ExtraCorporeal Life Support (ECLS).
Interventions
Collection of data from the following tests at H0 (as soon as the ECLS is put in place), H12 (within 12 hours following stabilisation of the dynamic state), H24 and every day until complete neurological recovery: * right and left pupillometry (3 times) * BIS values * right and left NIRS values * right and left transcranial Doppler * neurological clinical examination
OTHERneurological assessment when a neurological event occurs
next neurological event: * seizures * pupillary asymmetry * myoclonias * brain stem reflex abnormalities * osteotendinous reflex abnormalities
OTHERmortality assessment
to 28 days
Sponsors
Centre Hospitalier Universitaire Dijon
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients with brain lesions on veno-arterial circulatory support after cardiac arrest or cardiogenic shock who require at least 24 hours of sedation
Exclusion criteria
* Extubation expected within the first 24 hours of management * Minor patient * Pregnant women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Early mortality assessment | 28 days |
Countries
France
Contacts
Primary ContactMohamed Omar ELLOUZE
Outcome results
None listed