Childhood Obesity, Hereditary Transmission, Host and Microbiome, Immune Development, Neurodevelopment
Conditions
Keywords
Maternal Grandmother, Genes, Immune, Cohort, Child development
Brief summary
The MGBIG is a study exploring cross-generational effects in 5000 women and their children and grandchildren located in Guangzhou, China. Its initial aim is to facilitate research on understanding the interplay between genes and environmental factors on disease etiology and on explaining the cause of the disease from the perspective of "grandmother-mother-child" heredity. Data are collected regarding environmental exposures, lifestyle, and social support on grandmother from birth to old age. Biological samples including blood and tissue samples are collected.
Detailed description
It was previously believed that heredity strictly follows Mendel's laws, but recent studies have found that through placental material exchange, mammals may transfer maternal immune-related factors vertically, thus promoting the protection of "non-heredited maternal antigenic traits". Thus, the transmission of reproductive information across generations is realized. Since the unusual genetic pattern of the X chromosome, grandmother's influence may be gender specific. Since grandchildren were usually took care by grandparents in China, it could be achievable to attach and recruit maternal grandmother together with mother and children. Cohort including three generations of women is rare in Asia at present. In the MGBIG, extensive information including demographic characteristics, lifestyle, history of diseases, mental health, and behaviors is collected from the participants. Longitudinal follow up and surveillance of common chronic diseases are also to be conducted. The MGBIG intends to recruit maternal grandmothers to study the effects of maternal genetic and environmental exposure on the health of their children and grandchildren.
Interventions
None listed
Sponsors
Guangzhou Women and Children's Medical Center
Children's Hospital Medical Center, Cincinnati
University of Birmingham
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
36 Years to 100 Years
Healthy volunteers
Yes
Inclusion criteria
1. Maternal Grandmother' grandchildren delivered in Guangzhou Women and Children's Medical Center 2. Baseline information of maternal grandmother's daughter during pregnancy available
Exclusion criteria
1. Significant cardiovascular abnormalities 2. Intelligent obstacle, intellectual disabilities or gawkish condition
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Haplotypes transfered by non-inherited maternal antigens from maternal grandmother to female offspring | From the date of her daughter get pregnant until the date her grandchild/grandchildren is/are given birth | Assessed by analyses of MHC haplotypes, HLA haplotypes, and levels of non-inherited maternal antigens of mother and offspring, and pregnancy complication of maternal grandmothers and mothers |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Serum levels of Inflammatory factors at grandchildren's birth and early neonatal life | At the birth date of her grandchild/grandchildren, at the date 42 days after the birth of the certain grandchild/grandchildren | Assessed by analyses of IL-1, IL-6, IL-10, IL-12, etc. |
| The prevalence of eczema of grandchildren | At the age of 6 weeks, 6 months, 1year, 3 years, 6 years, 12years and 18years of grandchildren | Assessed by self-reported time of onset and electronic medical record |
| The incidence of asthma of grandchildren | At the age of 6 months, 1year, 3 years, 6 years, 12years and 18years of grandchildren | Assessed by self-reported time of onset and electronic medical record |
| The prevalence of Allergic rhinitis of grandchildren | At the age of 6 months, 1year, 3 years, 6 years, 12years and 18years of grandchildren | Assessed by self-reported time of onset and electronic medical record |
| The prevalence of Food allergy of children and grandchildren | At the age of 6 months, 1year, 3 years, 6 years, 12years and 18years of grandchildren | Assessed by self-reported time of onset and electronic medical record |
| Changes of body composition of grandchildren | At age of 3 years,6 years, 12years and 18years | Body composition is assessed using Dual Energy X-Ray Absorptiometry |
| Changes of bone density of grandchildren | At age of 3 years,6 years, 12years and 18years | Bone density is assessed using Dual Energy X-Ray Absorptiometry |
Countries
China
Contacts
CONTACTXiu Qiu, PhD
CONTACTXueling Wei, MS
PRINCIPAL_INVESTIGATORXiu Qiu, PhD
Guangzhou Women and Children's Medical Center, China
Outcome results
None listed