Migraine Disorders, Tenderness, Muscle, Headache Disorders
Conditions
Keywords
Ultrasound elastography, Pressure pain threshold, variation
Brief summary
The aim is to establish how headache and migraine can affect muscle hardness and tenderness in migraine patients
Detailed description
Migraine is a very common disorder, and many migraine patients have symptoms from their neck and muscles. 50% of migraine patients have a sensation of stiff neck in relation to migraine attacks. Furthermore it is well established, that migraine patients have tender muscles during migraine attack, which can be measured with pressure pain threshold. In this study the investigators aim to establish the variation in ultrasound elastography and pressure pain threshold in migraine patients over time. And establish the significance of headache, migraine and prodromes on these measurements. The study includes daily measurements of muscle hardness and muscle tenderness. The patients are asked to fulfill a headache diary and a short questionnaire asking about current headache, physical activity, stress and current infectious diseases. Sleep and physical activity is also measured objectively using a fitbit Charge2. Furthermore the patients are asked about symptoms which often are associated with migraine (prodromes).
Interventions
Measuring muscle hardness at the trapezius and neck bilateral
Measuring Pressure pain threshold at the trapezius and neck bilateral
Sponsors
Danish Headache Center
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Inclusion criteria
* Migraine Patient fulfilling international classification of headache disorders (ICHD 3) criteria
Exclusion criteria
* regular medication use other than medication for migraine or headache * Other Pain disorders * Musculoskeletal disorders affecting neck or upper body
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Effect of migraine on muscle tenderness | Daily measurements for about 30-60 days in a row | Muscle tenderness will be measured every day with pressure pain threshold. Migraine and headache is noted in a headache diary. Is the next measurement of muscle tenderness after migraine attack higher than those with out temporal proximity to headache. (paired T-test) |
| Effect of migraine on muscle hardness | Daily measurements for about 30-60 days in a row | Muscle hardness will be measured every day with Ultrasound elastography. Migraine and headache is noted in a headache diary. Is the next measurement of muscle tenderness after migraine attack higher than those with out temporal proximity to headache. (paired T-test) |
| Regression analysis of muscle hardness | Daily measurements for about 30-60 days in a row | Muscle hardness as the dependent variable and the following as the independent variables: Current migraine, Days until next migraine attack, days since last migraine attack, Sleep quality, physical activity, Stiff Neck (subjective feeling). The result shows how much of the variability in muscle hardness that can be explained by the independent variables. |
| Regression analysis of muscle tenderness | Daily measurements for about 30-60 days in a row | Muscle tenderness as the dependent variable and the following as the independent variables: Current migraine, Days until next migraine attack, days since last migraine attack, Sleep quality, physical activity, stiff neck (subjective feeling). The result shows how much of the variability in muscle hardness that can be explained by the independent variables. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Day to day variation of muscle hardness in non-headache days | Daily measurements for about 30-60 days in a row | Muscle hardness will be measured every day with Ultrasound elastography. Migraine and headache is noted in a headache diary. |
| Effect of tension type headache on muscle tenderness. | Daily measurements for about 30-60 days in a row | Muscle tenderness will be measured every day with pressure pain threshold. Migraine and headache is noted in a headache diary. Is the measurements performed on headache days higher than those with out temporal proximity to headache. |
| Day to day variation of muscle tenderness in non-headache days | Daily measurements for about 30-60 days in a row | Muscle tenderness will be measured every day with pressure pain threshold. Migraine and headache is noted in a headache diary. |
| Prodromes in migraine patients assessed by self-reported questionnaires | Patients are every day asked of symptoms for the last 24 hours and current symptoms | Descriptive data of how often migraine patients experience prodrome like symptoms |
| Effect of tension type headache on muscle hardness | Daily measurements for about 30-60 days in a row | Muscle hardness will be measured every day with Ultrasound elastography. Migraine and headache is noted in a headache diary. Is the measurements performed on headache days higher than those with out temporal proximity to headache. |
Countries
Denmark
Outcome results
None listed