Multiple Sclerosis
Conditions
Keywords
Multimodal Evoked potentials, Visual evoked potentials, Somato-sensory evoked potentials, Motor evoked potentials, Expanded Disability Status Scale (EDSS)
Brief summary
Utility of Multimodal Evoked potentials (mmEP) for monitoring disease course and prediction of progression at different stages of Multiple Sclerosis (MS) is investigated
Interventions
DIAGNOSTIC_TESTmultimodal evoked potentials (mmEP)
combination of visual evoked potentials (VEP) and motor evoked potentials (MEP) or the combination of VEP, MEP and somato-sensory evoked potentials (SSEP)
Sponsors
University Hospital, Basel, Switzerland
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* diagnosed with a clinically isolated syndrome (CIS) or MS with a relapsing-remitting (RRMS) or a primary progressive disease course (PPMS): * CIS: EDSS \<= 5.5 within six months of first clinical event * early RRMS: EDSS: \<= 3.5 disease course of 5 up to 10 years * late RRMS: EDSS: 2.0-5.5 inclusive disease course of 5 to 15 years * PPMS: EDSS: 2.0-6.5 inclusive disease course up to 15 years * participation in the Swiss Multiple Sclerosis Cohort Study (SMSC) * mental ability to cooperate * written informed consent
Exclusion criteria
* alcohol or substance abuse * progressive disease other than Multiple Sclerosis * psychiatric disorder requiring a treatment by a psychiatrist * patients with movable metal implants, e.g. pace-maker, stents, deep brain stimulators etc.;(patients with jaw- or bone-fixed metal implants can be included)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| correlation of EP-sum-score (Σ-EP) and the Expanded Disability Status Scale (EDSS) | 3 years | logistic regression model will be used to predict worsening in EDSS defined by a 1-point-change (0.5 if EDSS is 5.5 or higher) at year 3 |
Countries
Switzerland
Outcome results
None listed