Oxidative Stress, Pain, Postoperative
Conditions
Brief summary
The aim of the study is to investigate the effect of preoperative epidural dexmedetomidine compared to dexamethasone on postoperative pain control, analgesic consumption and oxydative stress response in patients undergoing thoracic surgery
Detailed description
The aim of the study is to investigate the effect of preoperative epidural dexmedetomidine compared to dexamethasone on postoperative pain control, analgesic consumption and oxydative stress response in patients undergoing thoracic surgery. Investigation will include patients between 30-70 years undergoing thoracic surgery due to malignant process of lung or oesophagus. Patients are divided in two groups: epidural administration of 0.375% ropivacaine with 1 mcg/kg dexmedetomidine (group 1) and epidural administration of 0.375% ropivacaine with 8 mg dexamethasone.
Interventions
DRUGDexmedetomidine Injection [Precedex]
epidural administration of dexmedetomidine added to ropivacaine
Sponsors
University Hospital Dubrava
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Age
30 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* patients undergoing thoracic surgery due to malignant process of lung or oesophagus ASA (American Society of Anesthesiologists) status I-III
Exclusion criteria
* neurological or psychiatric disease * corticosteroid therapy * anamnesis of myocardial infarct within last 6 months * severe aortic stenosis * kidney insufficiency * liver insufficiency * allergy * coagulation disorders
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in postoperative pain level using visual analogue scale | Before operation, 1 hour, 2 hour, 6 hour and 24 hour after operation | Change in baseline postoperative pain level measured before operation, and then at 1h, 2h, 6h and 24h after operation using visual analogue scale. Visual analogue scale is numerical scale in range from 1-10, assessing pain level. Minimum score is 1, which represents- no pain to maximum score 10 which represents- the worst pain ever experienced. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| analgesic consumption | 24 hour | analgesic consumption in time interval |
| oxydative stress level | 24 hour | malonyldialdehyde, glutathion, catalase |
Countries
Croatia
Contacts
Primary ContactJasminka Persec, Assist Prof
Backup ContactAndrej Sribar, MD PhD
Outcome results
None listed