Contemporary Clinical Management Of Acute Pulmonary Embolism

Conditions

Acute Pulmonary Embolism

Keywords

Acute pulmonary embolism, International guidelines

Brief summary

Acute pulmonary embolism is a potentially life-threatening disease with short-term mortality ranges from less than 1% to more than 30% during the hospital stay. Recent guidelines recommend to tailor diagnosis hospitalization and acute treatment based on the estimated risk for short-term Death. The assessment of the contemporary clinical management of patients with acute pulmonary embolism across different specialties would be of crucial value.

Detailed description

This is a prospective, non-interventional, multicenter study in patients with acute pulmonary embolism admitted to Cardiology, Emergency and Internal Medicine Departments in Italy. The aim of the study is to assess contemporary management strategies in patients with acute pulmonary embolism in terms of diagnosis, risk stratification, hospitalization and treatment in Italy and assess 1. their association with in-hospital and 30-day mortality and 2. their adherence to current guidelines of the European Society of Cardiology (ESC).

Becattini C, Vedovati MC, Colombo S, Vanni S, Abrignani MG, Scardovi AB, Marrazzo A, Borselli M, Barchetti M, Fabbri A, Dentali F, Maggioni AP, Agnelli G, Gulizia MM, COntemporary management of Pulmonary Embolism (COPE) Investigators.

2024-05-278 citations

10.1016/j.jtha.2024.04.025

Contemporary anticoagulant treatment strategies in patients with acute pulmonary embolism at different risk for death

Cecilia Becattini, Giancarlo Agnelli, M. Diamanti, Aldo P. Maggioni, Simone Vanni et al. (14 authors)

Vascular Pharmacology2023-11-253 citations

10.1016/j.vph.2023.107245

Acute pulmonary embolism and cancer: findings from the COPE study

Cecilia Becattini, Ludovica Anna Cimini, Giorgio Bassanelli, Aldo P. Maggioni, Fulvio Pomero et al. (19 authors)

Clinical Research in Cardiology2023-11-157 citations

10.1007/s00392-023-02323-z

Contemporary Management and Clinical Course of Acute Pulmonary Embolism: The COPE Study

Cecilia Becattini, Giancarlo Agnelli, Aldo P. Maggioni, Francesco Dentali, Andrea Fabbri et al. (15 authors)

Thrombosis and Haemostasis2023-02-0930 citations

10.1055/a-2031-3859

Contemporary clinical management of acute pulmonary embolism: the COPE study

Cecilia Becattini, Giancarlo Agnelli, Aldo P. Maggioni, Francesco Dentali, Andrea Fabbri et al. (10 authors)

Internal and Emergency Medicine2022-01-047 citations

10.1007/s11739-021-02855-0

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

No

Inclusion criteria

* Patients with acute, symptomatic acute pulmonary embolism * Age ≥ 18 years * Informed consent

Exclusion criteria

* refusal of informed consent * participation in controlled trials on the management of patients with acute pulmonary embolism

Design outcomes

Primary

Measure	Time frame	Description
In-hospital death	30 days	In-hospital Death and Death at 30 days

Secondary

Measure	Time frame	Description
All cause Mortality and clinical worsening	30 days	Death or clinical deterioration at 30 days from the diagnosis of pulmonary embolism
Pulmonary embolism related mortality for and clinical worsening	30 days	Pulmonary embolism-related death or clinical deterioration at 30 days from the diagnosis of pulmonary embolismembolism
Adherence to guidelines	30 days	Adherence to current guidelines on the management of acute pulmonary embolism released by the ESC regarding diagnosis, risk stratification and treatment

Countries

Italy

Outcome results