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Feasibility Study and Preliminary Application Study on Iris OCTA

Feasibility Study and Preliminary Application Study on Noninvasive Iris Optical Coherence Tomography Angiography (OCTA)

Status
UNKNOWN
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT03631108
Enrollment
4000
Registered
2018-08-15
Start date
2018-10-31
Completion date
2019-06-30
Last updated
2018-09-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Conjunctivitis, Diabetic Retinopathy, Glaucoma, Myopia, Retinal Detachment, Retinal Neovascularization, Unspecified, Uveitis

Keywords

Iris Vessel, OCTA

Brief summary

All participants will underwent imaging using the OCTA system (Zeiss) with the anterior segment optical adaptor lens. The main outcomes are iris blood flow density and vascular density.

Detailed description

1. Feasibility study of iris OCTA technology 2. Establishment of iris OCTA database in normal population and analysis of related factors: (1) different sex; (2) different age; (3) different myopic diopter; (4) 24-hour diurnal changes from morning to night; (5) before and after mydriasis; (6) different blood pressure; (7) different intraocular pressure; (8) different blood glucose; (9) before and after exercise. (10) drinking water, tea, coffee and red wine. 3. Analysis of iris OCTA data related to eye diseases:(1) conjunctivitis; (2) glaucoma; (3) childhood myopia; (4) uveitis; (5) diabetic retinopathy; (6) retinal detachment; (7) fundus neovascularization. 4. Influence of commonly used ophthalmic drops on iris OCTA data. Observe the difference of iris OCTA test data before and after treatment: (1) conjunctivitis treated with levofloxacin antibiotics; (2) glaucoma treated with prostaglandins, adrenalines and receptor blockers; (3) childhood myopia treated with atropine drugs (4) uveitis treated with hormonal drugs. (5) diabetic retinopathy treated with vasodilator. 5. Effect on iris OCTA data before and after ophthalmic surgery. (1) cataract, phacoemulsification + intraocular lens implantation; (2) glaucoma, iridectomy; (3) fundus neovascularization, intraocular injection of anti-VEGF; (4) diabetic retinopathy, vitreous surgery.

Interventions

DIAGNOSTIC_TESTOCTA (ZEISS)

All participants will underwent imaging using the OCTA system (Zeiss) with the anterior segment optical adaptor lens.

Sponsors

Shanghai Eye Disease Prevention and Treatment Center
Lead SponsorOTHER

Study design

Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL

Eligibility

Sex/Gender
ALL
Healthy volunteers
Yes

Inclusion criteria

* Healthy volunteers and ophthalmological patients who can understand and agree to cooperate this study will be included.

Exclusion criteria

* Patients who can not cooperate with the examination.

Design outcomes

Primary

MeasureTime frameDescription
Iris Vessel Geometric Characteristics0:00 8:00 14:00 20:00Iris vascular density and neovascular density

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 9, 2026