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Ventilator Hyperinflation and Manual Rib Cage Compression

Comparison Between Ventilator Hyperinflation and Manual Rib Cage Compression: Randomized Crossover Trial

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT03630484
Enrollment
30
Registered
2018-08-15
Start date
2014-11-28
Completion date
2017-07-11
Last updated
2018-08-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pulmonary Atelectasis

Keywords

Ventilator Hyperinflation, Expiratory Rib Cage Compression, Physical Therapy, Mechanical Ventilation

Brief summary

This is a randomized crossover trial to evaluate the effects of thoracic compression applied alone or in association with hyperinflation maneuver with the ventilator. In addition, the mobilized volume and peak expiratory flow resulting from both maneuvers will be evaluated.

Detailed description

Ventilator hyperinflation is widely used in hypersecretive patients. It consists of increasing alveolar ventilation by facilitating the coughing mechanism so that the secretions of the peripheral airways are mobilized into the central airways so that they can be removed by tracheal aspiration or cough. Thoracic compression consists of manually compressing the rib cage during expiration, in order to increase expiratory flow, mobilize and remove pulmonary secretions. A randomized crossover clinical trial was performed with 30 patients submitted to isolated compression or associated with ventilator hyperinflation, with a 6 hour interval. Patients were evaluated through compliance and resistance of the respiratory system.

Interventions

Compression was performed in 6 sets of 6 cycles, with 1 cycle interval. Ventilatory mode and parameters were maintained.

OTHERCompression + Ventilator Hyperinflation

Mechanical ventilator hyperinflation was performed by increasing the inspiratory pressure to every 5 cmH2O until the total pressure reached 40 cmH2O, remaining the same. In Expiratory Rib Cage Compression associated with ventilator hyperinflation, thoracic compression maneuver was performed at the end of inspiration, at the exact moment of cycling.

Sponsors

Brazilian Institute of Higher Education of Censa
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No

Inclusion criteria

* patients under mechanical ventilation * diagnosis of pulmonary infection * hypersecretive

Exclusion criteria

* haemodynamic instability (heart rate \> 130 bpm and mean arterial pressure \< 60 mmHg) * acute bronchospasm * acute respiratory distress syndrome * untreated pneumothorax

Design outcomes

Primary

MeasureTime frameDescription
Static compliance of respiratory systemBaseline (before), immediately after ventilator hyperinflation or rib cage compression and five minutes after aspirationCompliance was assessed through the occlusion maneuver at the end of inspiration, considering tidal volume, plateau pressure and PEEP. Three measurements were taken at each moment, the mean being used.
Total Resistance of respiratory systemBaseline (before), immediately after ventilator hyperinflation or rib cage compression and five minutes after aspirationThe total resistance of the respiratory system was evaluated through the occlusion maneuver at the end of the inspiration, considering the resistive pressure, measured by the difference between the maximum plateau pressure. Three measurements were taken at each moment, the mean being used.
Airway ResistanceBaseline (before), immediately after ventilator hyperinflation or rib cage compression and five minutes after aspirationThe airway resistance was assessed by means of the occlusion maneuver at the end of the inspiration, considering the rapid fall of the pressure immediately after the occlusion, measured by the difference between the maximum pressure and P1. Three measurements were taken at each moment, the mean being used.
Peak expiratory flowBaseline (before), immediately after ventilator hyperinflation or rib cage compression and five minutes after aspirationThe peak expiratory flow was evaluated through passive expiration, being considered the greatest value of the flow in the expiratory phase.

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026