Myocardial Infarction, Myocardial Injury
Conditions
Brief summary
The current diagnostic criteria for a heart attack require evaluation of a patient's symptoms and ECG but importantly a blood test called troponin. With advancing technology this test has become more sensitive and is now called a high sensitivity troponin. This is a very effective way of rapidly excluding a heart attack if the test is negative. However there are a number of causes of a raised high sensitivity other than a heart attack, particularly critical illness states. In the absence of features of a heart attack an abnormal result therefore suggests that the heart is inflamed or unwell causing the release of high sensitivity troponin. The DIGNITY study will examine the consequences of high sensitivity troponin elevation in patients in intensive care and assess whether it has a role as a biomarker for predicting outcome.
Interventions
None listed
Sponsors
University Hospital Southampton NHS Foundation Trust
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adult patients (aged 18 years or older) admitted to any of the three intensive care facilities on site (general, cardiac and neurosciences) * Biochemistry samples already taken as part of routine clinical care during the ICU stay
Exclusion criteria
* Patients aged less than 18 years * No biochemistry samples taken within the ICU stay
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Association between high sensitivity troponin and inpatient mortality on all patients admitted to each of the ICU environments at a large teaching hospital | During intensive care admission |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Distribution of high sensitivity troponin results for different admissions to intensive care | During intensive care admission | Distribution of high sensitivity troponin results in * Medical admissions * Trauma / emergency surgical admissions * Planned surgical admissions * Post cardiac surgical patients * Neurosurgical patients |
| Association between high sensitivity troponin results and duration of ventilation | Within twenty eight days | — |
| Association between high sensitivity troponin results and length of intensive care admission | Number of days not in intensive care within twenty eight days of original intensive care admission | — |
| Association between high sensitivity troponin results and requirement for inotropic support | During intensive care admission | — |
Countries
United Kingdom
Contacts
Primary ContactJonathan Hinton
Backup ContactZoe Nicholas
Outcome results
None listed