Cardiopulmonary Bypass, Congenital Heart Disease, Mechanical Ventilation Complication
Conditions
Brief summary
The study is about a protocol of protective mechanical ventilation during cardiopulmonary bypass used during cardiosurgery for the correction of congenital heart diseases, to evaluate what's the best for the lungs
Interventions
Mechanical ventilation during cardiopulmonary bypass
Sponsors
Azienda Ospedaliera di Padova
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
No minimum to 5 Years
Healthy volunteers
Yes
Inclusion criteria
* congenital heart diseases * younger than 5 years * CPB longer than 30 minutes in hypotermia * elective surgery * stable clinical conditions
Exclusion criteria
* genetic anomalies * mechanical ventilation before the surgery * kidney injuries * hepatic failure
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Evaluation of the damage of the air-blood membrane in a ventilation protocol and a non ventilation protocol during cardiopulmonary bypass | Baseline, and 6, 12, 24 and 48 hours after the surgery | It will be assed the plasma level of proteins which usually are absent in the plasma (surfactant protein A and B) that change as a damage of the air-blood membrane appears. |
Countries
Italy
Outcome results
None listed