Diagnosis of MGRS in Patients With Paraproteinemias: Clinical, Anatomopathological and Pathophysiological Study

Diagnosis of Monoclonal Gammopathy of Renal Significance in Patients With Paraproteinemias

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03629561

Acronym

MGRS-CAPS

Enrollment

Registered

2018-08-14

Start date

2019-02-23

Completion date

2021-02-28

Last updated

2019-02-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Monoclonal Gammopathy of Renal Significance

Keywords

Paraproteinemias[Mesh], Kidney Diseases[Mesh]

Brief summary

This is the first prospective study which evaluate patients with small B-cell clones to diagnose monoclonal gammopathy of renal significance (MGRS) and characterize it clinically, anatomopathologically and pathophysiologically taking int account a geriatric approach.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 89 Years

Healthy volunteers

Inclusion criteria

* Paraproteinemias

Exclusion criteria

* Multiple Myeloma * Waldenstrom Macroglobulinemia * Chronic Lymphocytic Leukemia * Malignant Lymphoma * Monoclonal gammopathy of unknown significance (MGUS) secondary to Infections * MGUS secondary to Autoimmune Diseases * Uncompleted hematological evaluation * Renal tumor except for cysts Bosniak type I/II * Other malignant neoplasia * Unresolved obstructive uropathy * Patients with only one kidney except for renal transplant * Co-morbidities which would limit the ability to receive aggressive therapeutic intervention * Fragile old people * Pregnancy * Prison * Impatient in psychiatric institutions.

Design outcomes

Primary

Measure	Time frame
Renal histopathology compatible with MGRS	through study completion, an average of 1 year

Secondary

Measure	Time frame
Renal physiopathological changes	through study completion, an average of 1 year

Countries

Argentina

Contacts

Primary ContactMariana Ciocchini, Nephrologist

marianaciocchini@pm.me+54 9 11 6172 2738

Outcome results