Intrauterine Adhesion
Conditions
Brief summary
Effect of platelet-rich plasma (PRP) on uterine scar fibrosis, endometrial receptivity and pregnancy outcome in patients with severe intrauterine adhesions
Detailed description
1. Inclusion criteria: patients with intrauterine adhesions (AFS score \>9 points); age 21 to 40 years old, with fertility requirements. 2. Study design:prospective, randomized controlled cohort study, patients with intrauterine adhesions were randomized into two groups, the control group and the intervention group (intraoperative and postoperative 1 week postoperative PRP). The surgical procedures and postoperative medication regimens were the same. 3. Compare the biochemical pregnancy rate, clinical pregnancy rate, abortion rate and live birth rate after hysteroscopic resection in PRP group and control group, and explore the effect of PRP on pregnancy outcome after intrauterine adhesion.
Interventions
PROCEDUREPlatelet-rich plasma
Platelet-rich plasma intrauterine injection
PROCEDUREgel
Self-crosslinking sodium hyaluronate gel intrauterine injection
Sponsors
Yanhong Deng
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 37 Years
Healthy volunteers
No
Inclusion criteria
Patients with intrauterine adhesions (AFS score \>9 points); age 21 to 40 years old, with fertility requirements -
Exclusion criteria
Endometrial tuberculosis, endometrial polyps, uterine submucosal fibroids, endometrial hyperplasia, endometrial malignant lesions, premature ovarian failure, chromosomal abnormalities \-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| AFS score | 1 year | AFS score |
Outcome results
None listed