Non-invasive Evaluation Program for TIPS and Follow Up Network

Conditions

Portal Hypertension

Keywords

transjugular intrahepatic portosystemic shunt (TIPS), non-invasive assessments, Transthoracic echocardiography (TTE) with Speckle-tracking, Computer tomography scan (CT-scan), Magnetic resonance imaging (MRI), circulating biomarkers, Electroencephalography (EEG)

Brief summary

Evaluation of non-invasive prognostic parameters in patients receiving transjugular intrahepatic portosystemic shunt (TIPS) for complications of portal hypertension. Patients are cared according to the local standardized follow up program. Clinical and laboratory data from standard patient care are evaluated for potential prognostic value.

Detailed description

NEPTUN consists of liver cirrhosis receiving transjugular intrahepatic portosystemic shunt (TIPS) at the Department of Internal Medicine I, University of Bonn, Germany and receiving a structured routine evaluation and follow up program. The diagnosis of cirrhosis was based on clinical, hemodynamic and biochemical parameters, and ultrasound and/or biopsy criteria.

Yi Jin, Frederick Clasen, Fernando Garcia‐Guevara, Sania Arif, Robert Schierwagen et al. (22 authors)

iMeta2026-05-07

10.1002/imt2.70131

Three‐Dimensional Transjugular Intrahepatic Portosystemic Shunt Geometry Predicts Shunt Dysfunction

Carsten H. Meyer, Markus Kimmann, Katharina Böhm, Sebastian Nowak, Alba Maria Paar Pérez et al. (14 authors)

Alimentary Pharmacology & Therapeutics2025-04-094 citations

10.1111/apt.70133

Targeted decrease of portal hepatic pressure gradient improves ascites control after TIPS

Alexander Queck, Louise Schwierz, Wen Gu, Philip G. Ferstl, Christian Jansen et al. (15 authors)

Hepatology2022-07-2331 citations

10.1002/hep.32676

Controlled underdilation using novel VIATORR® controlled expansion stents improves survival after transjugular intrahepatic portosystemic shunt implantation.

Praktiknjo M, Abu-Omar J, Chang J, Thomas D, Jansen C, Kupczyk P, Schepis F, Garcia-Pagan JC, Merli M, Meyer C, Strassburg CP, Pieper CC, Trebicka J.

2021-03-0351 citations

10.1016/j.jhepr.2021.100264

Sex specificity of kidney markers to assess prognosis in cirrhotic patients with TIPS

María Torner, Adjmal Mangal, Hubert Scharnagl, Christian Jansen, Michael Praktiknjo et al. (16 authors)

Liver International2019-08-2615 citations

10.1111/liv.14230

Collagen type IV remodelling gender‐specifically predicts mortality in decompensated cirrhosis

Jennifer Lehmann, Michael Praktiknjo, Mette Juul Nielsen, Robert Schierwagen, Carsten H. Meyer et al. (14 authors)

Liver International2019-02-1033 citations

10.1111/liv.14070

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

OTHER

Eligibility

Sex/Gender

ALL

Age

18 Years to 100 Years

Healthy volunteers

No

Inclusion criteria

* Insertion of TIPS according to guidelines

Exclusion criteria

* Contraindication for TIPS

Design outcomes

Primary

Measure	Time frame	Description
Survival	up to 10 years	death, liver transplantation

Secondary

Measure	Time frame	Description
Ascites	up to 10 years	Evaluation of amount of ascites according to the Child-Score
Hepatic Encephalopathy	up to 10 years	Evaluation of the grade according to the West Haven Criteria
Organ Failures	up to 10 years	Assessment of Organ failures according to the CLIF-SOFA according to CLIF-Sequential Organ Failure Assessment (SOFA) Score
Liver Failure	up to 10 years	defined as Bilirubin level ≥ 12mg/dl
Acute-on-Chronic-Liver Failure (ACLF)	up to 10 years	Presence of ACLF according to the EASL-Chronic liver Failure Consortium (CLIF)-criteria
Variceal Bleeding	up to 10 years	Assessment of presence of variceal bleeding

Countries

Germany

Outcome results