Tourette Syndrome
Conditions
Brief summary
Tics are the hallmark symptoms in Tourette Syndrome. Patients with Tourette Syndrome have difficulties controlling unwanted movements. The ability to control the motor system involves the pre-supplementary motor area (pre-SMA) in the brain. In this study, we will use Transcranial Magnetic Stimulation to modulate the pre-SMA and determine effect on the ability to stop an unwanted action in a behavior task (stop signal task).
Interventions
DEVICERepetitive TMS
Repetitive Intermittent Theta-Burst Transcranial Magnetic Stimulation over the right Pre-supplementary Motor Area
Sponsors
Children's Hospital Medical Center, Cincinnati
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
10 Years to 17 Years
Healthy volunteers
No
Inclusion criteria
* Tourette Syndrome
Exclusion criteria
* Autism spectrum disorder * Mood disorder * Epilepsy * Implanted medical device (e.g. pacemaker, shunt, pumps)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Stop Signal Reaction Time (SSRT) | 30 minutes after Repetitive Transcranial Magnetic Stimulation (as it takes about 30 minutes to complete the modified Slater-Hammel stop signal task) | SSRT measured from modified Slater-Hammel stop signal task performance. The SSRT is calculated by subtracting the average stop signal delay (msec) from the average go-trial reaction time. The SSRT is a measure of inhibitory behavior. The lower the SSRT value means a person is better at inhibitory control. The higher the SSRT value means a person is worse at inhibitory control. |
Countries
United States
Participant flow
Participants by arm
| Arm | Count |
|---|---|
| Repetitive TMS Repetitive Intermittent Theta-Burst Transcranial Magnetic Stimulation
Repetitive TMS: Repetitive Intermittent Theta-Burst Transcranial Magnetic Stimulation over the right Pre-supplementary Motor Area | 10 |
| Total | 10 |
Baseline characteristics
| Characteristic | Repetitive TMS |
|---|---|
| Age, Continuous | 14.9 years STANDARD_DEVIATION 3.8 |
| Race (NIH/OMB) American Indian or Alaska Native | 0 Participants |
| Race (NIH/OMB) Asian | 0 Participants |
| Race (NIH/OMB) Black or African American | 0 Participants |
| Race (NIH/OMB) More than one race | 0 Participants |
| Race (NIH/OMB) Native Hawaiian or Other Pacific Islander | 0 Participants |
| Race (NIH/OMB) Unknown or Not Reported | 0 Participants |
| Race (NIH/OMB) White | 10 Participants |
| Region of Enrollment United States | 10 participants |
| Sex: Female, Male Female | 3 Participants |
| Sex: Female, Male Male | 7 Participants |
| Yale Global Tic Severity Scale | 19.3 units on a scale STANDARD_DEVIATION 10.1 |
Adverse events
| Event type | EG000 affected / at risk |
|---|---|
| deaths Total, all-cause mortality | 0 / 10 |
| other Total, other adverse events | 0 / 10 |
| serious Total, serious adverse events | 0 / 10 |
Outcome results
Primary
Stop Signal Reaction Time (SSRT)
SSRT measured from modified Slater-Hammel stop signal task performance. The SSRT is calculated by subtracting the average stop signal delay (msec) from the average go-trial reaction time. The SSRT is a measure of inhibitory behavior. The lower the SSRT value means a person is better at inhibitory control. The higher the SSRT value means a person is worse at inhibitory control.
Time frame: 30 minutes after Repetitive Transcranial Magnetic Stimulation (as it takes about 30 minutes to complete the modified Slater-Hammel stop signal task)
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Repetitive TMS | Stop Signal Reaction Time (SSRT) | Before Repetitive TMS | 249 milliseconds | Standard Deviation 28 |
| Repetitive TMS | Stop Signal Reaction Time (SSRT) | After Repetitive TMS | 245 milliseconds | Standard Deviation 11.2 |
p-value: 0.49t-test, 2 sided