Osteoarthritis, Knee
Conditions
Keywords
muscle tension, alignment, knee osteoarthritis, loading
Brief summary
Knee osteoarthritis (KOA) is a common chronic painful musculoskeletal condition among older adults. It poses great challenge to the health care system due to its inability to be cured. Understanding factors associated with disease progression in KOA should assist the development of novel prevention/rehabilitation strategies. This study investigate factors including muscle properties, lower limb alignment and joint loading in patients with knee osteoarthritis before and after a six-week exercise program.
Interventions
OTHERExercise
Comprehensive exercise program including strengthening, stretching, gait modification etc.
Sponsors
Queen Mary Hospital, Hong Kong
The Hong Kong Polytechnic University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
50 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
1. Age between 50-80 2. having radiographic tibiofemoral joint OA in the medial compartment defined as Kellgren and Lawrence grade = 2 to 3 3. having medial knee pain on most days of the month 4. having a minimum average pain score of 2 on an 11-point numerical rating scale in the past week while walking
Exclusion criteria
1. having lateral tibiofemoral compartment osteophytes greater than the medial side. 2. having undergone intra-articular corticosteroid injection or knee surgery to either knee within the past 3 months 3. having a systemic arthritic condition (e.g., rheumatoid arthritis) 4. having a knee joint replacement or high tibial osteotomy in the past 5. having any other muscular, joint or neurological condition influencing lower limb function 6. unable to walk unaided 7. having low back, hip, ankle or foot pain \> 3 on numerical rating scale 8. having a body mass index (BMI) \>36 kg/ m2
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change of External Knee Adduction Moment as Assessed by Visual Motion Analysis System | At baseline and one week after intervention | External knee moment in the frontal plane during early stance phase of walking |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change of Pain Severity Score as Assessed by Knee Injury and Osteoarthritis Outcome Score | At baseline and one week after intervention | Pain intensity measured by the pain subscale of Knee injury and Osteoarthritis Outcome Score (KOOS). The minimum value is 0 and maximum value is 100. The higher scores mean a better outcome. |
| Tibial Torsion as Assessed by X-ray Imaging | At baseline | The angle between tibial and femur in the transverse plane |
| Change of Young's Modulus of Quadriceps as Assessed by Ultrasound Elastography | At baseline and one week after intervention | Young's modulus by ultrasound elastography |
Countries
Hong Kong
Participant flow
Participants by arm
| Arm | Count |
|---|---|
| Exercise Six-week exercise including stretching, strengthening, endurance and gait modification
Exercise: Comprehensive exercise program including strengthening, stretching, gait modification etc. | 40 |
| Total | 40 |
Withdrawals & dropouts
| Period | Reason | FG000 |
|---|---|---|
| Overall Study | Lost to Follow-up | 1 |
Baseline characteristics
| Characteristic | Exercise | — |
|---|---|---|
| Age, Continuous | 63 years STANDARD_DEVIATION 6 | — |
| Race and Ethnicity Not Collected | — | — Participants |
| Region of Enrollment Hong Kong | 40 participants | — |
| Sex: Female, Male Female | 29 Participants | — |
| Sex: Female, Male Male | 11 Participants | — |
Adverse events
| Event type | EG000 affected / at risk |
|---|---|
| deaths Total, all-cause mortality | 0 / 40 |
| other Total, other adverse events | 0 / 40 |
| serious Total, serious adverse events | 0 / 40 |
Outcome results
Primary
Change of External Knee Adduction Moment as Assessed by Visual Motion Analysis System
External knee moment in the frontal plane during early stance phase of walking
Time frame: At baseline and one week after intervention
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Exercise | Change of External Knee Adduction Moment as Assessed by Visual Motion Analysis System | 0.50 Nm/kg | Standard Deviation 0.13 |
Secondary
Change of Pain Severity Score as Assessed by Knee Injury and Osteoarthritis Outcome Score
Pain intensity measured by the pain subscale of Knee injury and Osteoarthritis Outcome Score (KOOS). The minimum value is 0 and maximum value is 100. The higher scores mean a better outcome.
Time frame: At baseline and one week after intervention
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Exercise | Change of Pain Severity Score as Assessed by Knee Injury and Osteoarthritis Outcome Score | 70 Score on a scale | Standard Deviation 14 |
Secondary
Change of Young's Modulus of Quadriceps as Assessed by Ultrasound Elastography
Young's modulus by ultrasound elastography
Time frame: At baseline and one week after intervention
Secondary
Tibial Torsion as Assessed by X-ray Imaging
The angle between tibial and femur in the transverse plane
Time frame: At baseline