Burn Scar
Conditions
Keywords
burn, scar, fat, grafting
Brief summary
fat grafting in human skin-grafted immature burn scars histological, clinical and photographic follow-up
Detailed description
Objective: A randomised clinical trial was performed to determine the effect of autologous fat grafting on scar formation in early skin-grafted deep burn wounds. Methods: Included patients received split-thickness skin grafting procedures for deep burn wounds less than 3 months ago. A homogenous scar area in each patient was divided into two equal parts. One part was treated with transcutaneous sharp needle autologous fat grafting, the adjacent part with transcutaneous saline injection as control. Results were evaluated by clinical assessment with scar scale questionnaires, histological examination, and objective scar assessment with Cutometer, Mexameter, Tewameter and Corneometer.
Interventions
PROCEDURElipofilling/ fat grafting
liposuction, processing/ cleaning of fat tissue; reinjection with sharp needle transcutaneous
PROCEDUREplacebo injection
Sponsors
University Hospital, Ghent
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Masking description
2 skin zones per participant, A and B, 1 is treated, 1 is placebo coin toss determines which zone will be treated, this information is kept in sealed envelope
Intervention model description
randomised controlled trial
Eligibility
Sex/Gender
ALL
Age
25 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* early skin-grafted deep burn scars * otherwise healthy
Exclusion criteria
* concomitant disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Improvement of scar quality by histological assessment | 6 months | histology of scar tissue, scoring by 2 independent blinded anatomopathologists, (numerical scoring of fibroblast activity, collagen and elastin organisation, vascularity) scoring range min 1(close to normal tissue) - 3 (scar characteristics) |
| improvement of scar quality by physiological testing with cutometer | 6 months, 1 year | measures elasticity of the scar; micrometer; higher values better outcome |
| Improvement of scar quality by subjective evaluation with numerical Vancouver Scar Scale | 1 year | numerical score 0 to 13; ranges vascularity, height/thickness, pliability, and pigmentation |
| Improvement of scar quality by subjective evaluation with numerical POSAS (Patient and Observer Scar Assessment Scale) Scale | 1 year | numerical score 5 to 50: VSS plus surface area; patient assessments of pain, itching, color, stiffness, thickness, relief |
| improvement of scar quality by physiological testing with TEWA-meter (Trans Epidermal Water Loss-meter) | 6 months, 1 year | measures transepidermal water loss; g/m2/h; higher values worse outcome |
| physiological testing of scar tissue by corneometer | 6 months, 1 year | measures hydration of the epidermis; corneometer units, higher values better outcome |
Outcome results
None listed