The Effect of Ginger on the Incidence of Postoperative Nausea and Vomiting

An Evaluation of the Effectiveness of a Single Dose of Preoperative Ginger on the Incidence of Postoperative Nausea and Vomiting in Patients Undergoing Elective Gynaecological Surgery

Status

Completed

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03626441

Enrollment

110

Registered

2018-08-13

Start date

2017-12-02

Completion date

2018-06-14

Last updated

2018-08-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative Nausea and Vomiting

Keywords

Postoperative Nausea and Vomiting, Ginger

Brief summary

This study evaluates the effectiveness of ginger on the incidence of postoperative nausea and vomiting in patients undergoing gynaecological surgery. Half the patients were given an oral dose of ginger preoperatively and half received placebo.

Detailed description

Postoperative nausea and vomiting (PONV) commonly complicate surgery and may lead to a prolonged length of stay in hospital, increased complication rates and decreased patient satisfaction. Gynaecological surgery is considered high risk for PONV. Ginger is a cheap, widely available and safe natural product in Jamaica and has been found to reduce the incidence of Nausea and vomiting in other clinical situations, such as in pregnancy. It is believed to act via the inhibition of serotonergic receptors.

Interventions

DIETARY_SUPPLEMENTGinger

Capsules containing 0.5g ginger powder, flavoured with non-active essence of ginger

DIETARY_SUPPLEMENTPlacebo

Two coloured capsules containing 0.5 mg of cornstarch and flavoured with non-active essence of ginger.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Masking description

Sequentially numbered, sealed, opaque envelopes prepared and opened the evening before the surgery. Tablets containing either placebo or ginger allocated by a person not involved in any other aspect of the study and administered on the morning of surgery.

Intervention model description

Quadruple, blind randomized, controlled trial

Eligibility

Sex/Gender

FEMALE

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Age 18 or above * Undergoing elective intra-abdominal, gynaecological surgery

Exclusion criteria

* Allergy to ginger, ginger by-products or cornstarch * Gastroesophageal reflux disease (GERD) * Allergy to any of the Anaesthesia Agents * Inability to swallow capsules. * psychiatric illness which prevents patients giving informed consent. * Psychological which prevents patients giving informed consent.

Design outcomes

Primary

Measure	Time frame	Description
Incidence of post operative nausea or vomiting	12 hours after surgery	The proportion of patient who have any episodes of nausea or vomiting following surgery

Secondary

Measure	Time frame	Description
Severity of post operative Nausea and vomiting	12 hours after surgery	Measured using the Rhodes index
Patient satisfaction	48 hours post surgery	Measured using a questionnaire administered to patient by investigators

Countries

Jamaica

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026