Iron Deficiency Anemia
Conditions
Brief summary
Iron-deficient anaemic subjects are likely to benefit most from oral iron supplements, but supplementation schedules vary widely in clinical practice, absorption is low and compliance is poor due to mild gastrointestinal side effects. The investigators will compare iron absorption from labeled oral iron doses of 100mg and 200mg administered either on two consecutive days or on alternate days in young anemic women.
Interventions
OTHERIron stable isotope labeled iron(II) sulfate
Administration of oral stable isotope labels using different dosings and different regimens in women with iron deficiency anemia
Sponsors
Swiss Federal Institute of Technology
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* Ferritin \<15 µg/L * Hb 8-11.9 g/dl * BMI 18.5-24.9 kg/m2 * Body weight \<70 kg
Exclusion criteria
* Severe anemia (Hb \<8 g/dl) * Elevated CRP \>5.0 mg/L * Chronic disease * Long-term medication, except contraception * Consumption of Mineral and Vitamin supplements within the study period * Therapeutic iron infusion over the past 6 months * Pregnancy or breastfeeding * Smoking
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Fractional and total iron absorption | absorption will be measured 14days after the 100mg and 200mg cycle | Fractional and total iron absorption from different supplementation regimens |
| Serum hepcidin | right before the administration of an iron dose | Serum hepcidin after the administration of different doses and using different regimens |
| Serum EPO | right before the administration of an iron dose | Serum EPO after the administration of different doses and using different |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Serum AGP | right before the administration of an iron dose | Determination of inflammation status |
| Serum ferritin | right before the administration of an iron dose | Determination of iron status |
| Total iron binding capacity | right before the administration of an iron dose | Determination of iron status |
| Serum iron | right before the administration of an iron dose | Determination of iron status |
| Serum TfR | right before the administration of an iron dose | Determination of iron status |
| Serum CRP | right before the administration of an iron dose | Determination of inflammation status |
Countries
Switzerland
Outcome results
None listed