Serrated Polyp Detection Rate Between Carbon Dioxide and Air Insufflation

Comparison of Serrated Polyp Detection Rate Between Carbon Dioxide and Air Insufflation During Colonoscopy: a Randomized Controlled Multicenter Trial

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03623906

Enrollment

1280

Registered

2018-08-09

Start date

2018-09-01

Completion date

2020-12-31

Last updated

2018-08-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Serrated Polyp

Brief summary

Sessile serrated adenomas are characterized by their flat shape and the presence of a yellow mucus cap overlying the lesion. These morphological features may account for their diagnostic difficulty during colonoscopy. Missed proximal sessile serrated adenomas are regarded as an important cause for interval cancers in the right colon and emphasize the importance of developing quality measures intended to enhance their detection. There is only one single-center retrospective cohort study on the impact of carbon dioxide insufflation on the detection of serrated polyps during colonoscopy. The investigators designed a randomized, controlled trial to compare the effect of carbon dioxide insufflation vs. room air insufflation on serrated polyp detection rate.

Interventions

PROCEDURECarbon dioxide insufflation colonoscopy

Carbon dioxide insufflation colonoscopy

PROCEDUREAir insufflation colonoscopy

Room air insufflation colonoscopy

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SCREENING

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

45 Years to 75 Years

Healthy volunteers

Inclusion criteria

Patients 45-75-years-old who underwent a colonoscopy -

Exclusion criteria

polyposis syndrome, Inflammatory bowel disease, previous colorectal operation \-

Design outcomes

Primary

Measure	Time frame
Serrated polyp detection rate	7 days

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026