Effect of Natural Antibacterial Mouthwash on Taste, Salivary pH and Bacteria in High Caries Risk pt

Effect of Propolis and Pomegranate Extract Mouthwash on Taste Alteration, Salivary pH and Antibacterial Activity in High Caries Risk Patients

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03623048

Enrollment

Registered

2018-08-09

Start date

2019-03-31

Completion date

2019-04-30

Last updated

2018-09-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Decay, Dental

Brief summary

Evaluate the effect of propolis extract mouthwash and pomegranate extract mouthwash on taste alteration, salivary pH and antibacterial activity against streptococcus mutans in high caries risk patients.

Detailed description

This study will be carried out to evaluate and compare the effect of propolis extract mouthwash and pomegranate (botanical name: Punica granatum) extract mouthwash on taste alteration, salivary pH and antibacterial activity against streptococcus mutans in high caries risk patients. Thats by taking unstimulated saliva samples at the morning before using the mouthwash, then taking another one after using the mouthwash and finally after 7 days, to make a bacterial culture and measure the salivary pH by a digital pH meter and evaluate taste changes by a questionnaire.

Interventions

OTHERchlorhexidine

antibacterial and anti-inflammatory mouthwash

OTHERsaline

anti-inflammatory cleansing mouthwash

OTHERPropolis extract

antibacterial mouthwash

OTHERpomegranate extract

antibacterial mouthwash

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

17 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

* High caries risk patients defined according to American Dental Association (ADA) * Systematically healthy * Not taking any medication interfering with saliva secretion * Subjects who signed informed consent * Age range from 17-50 years

Exclusion criteria

* Subjects suffering from any medical or systematic disease * Smokers * Pregnant females * Allergy to any of the mouthwash ingredients * Patients older than 50 years

Design outcomes

Primary

Measure	Time frame	Description
Taste alteration	One week	taste changes will be measured by a questionnaire

Secondary

Measure	Time frame	Description
Salivary pH	one week	salivary pH will be measured by digital pH meter

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026