Inflammation, Trauma
Conditions
Keywords
uric acid, organ failure
Brief summary
The goal of this project, is to better understand the fluctuation of the level of uric acid in traumatized patients by making serial measurements during their hospitalization in the intensive care unit. In addition, the determinants (e.g. type of trauma, diseases, interventions) of the blood level of uric acid and its association with the development of organ failure will be sought.
Interventions
None listed
Sponsors
Fonds de la Recherche en Santé du Québec
Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
* Direct admission to trauma center * ≤ 3h after trauma * ISS ≥ 16 * Received at least 1L of fluid at ER entrance
Exclusion criteria
* Isolated head injury * Isolated spine injury * Chemotherapy within the last month * Hematologic disease * Chronic hemodialysis * Uricase treatment within the last week * Expected death within 48h
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Feasibility of serial plasmatic uric acid sampling after trauma | 7 days | Number of measures collected/number of measures planned |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Impact of resuscitation on uric acid measures | 24 to 48 hours | Impact of fluid administration (amount in mL) on the changes of subsequent uric acid blood level |
| Clinical predictors of the first blood uric acid (μmol/L) level measured | 12 hours | Impact of patient's characteristics and physiological variables on the first measured blood uric acid. Characteristics will include: age (years), gender, Injury severity score, presence of acute renal impairment. Physiological variables will include: lower systolic blood pressure, base deficit, lactate level |
Countries
Canada
Outcome results
None listed