The Effect of Dexmedetomidine for Emergence Cough

The Effect of Dexmedetomidine on the Remifentanil Concentration for Preventing Cough During Emergence After Propofol Anesthesia

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03622502

Enrollment

Registered

2018-08-09

Start date

2018-08-16

Completion date

2019-03-27

Last updated

2020-01-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cough

Keywords

dexmedetomidine, remifentanil, extubation

Brief summary

Dexmedetomidine or remifentanil are effective in attenuating cough during peri-extubation period after general anesthesia. The purpose of this study was to investigate the effect of dexmedetomidine on the remifentanil concentration for the cough suppression during anesthetic emergence.

Detailed description

Administration of dexmedetomidine before end of surgery could reduce airway reflexes and hemodynamic changes during tracheal extubation. Compared with remifentanil alone, administration of dexmedetomidine in combination with remifentanil is effective in relieving cough and hemodynamic changes without inhibition of respiration. The purpose of this study was to investigate the effect of dexmedetomidine on the remifentanil concentration for the cough suppression during anesthetic emergence using the modified up-and-down method.

Interventions

DRUGDexmedetomidine

Dexmedetomidine 0.5mcg/kg was infused over 10 min before end of the surgery

DRUGRemifentanil

Remifentanil was maintained at predetermined effect-site concentration during the periextubation period (initial concentration: 2.0 ng/ml)

DRUGNormal saline

Normal saline was infused over 10 min before end of the surgery

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

DOUBLE (Caregiver, Investigator)

Eligibility

Sex/Gender

ALL

Age

19 Years to 65 Years

Healthy volunteers

Inclusion criteria

* ASA physical status I or II undergoing endoscopic sinus surgery or septoplasty under general anesthesia

Exclusion criteria

* predicted difficult airway * body mass index \> 35 kg/m2, * recent upper respiratory infection * asthma * current smoker * patients using angiotensin converting enzyme-inhibitors * uncontrolled hypertension

Design outcomes

Primary

Measure	Time frame	Description
Number of cough	from end of surgery to 5 min after tracheal extubation]	Number of cough or a strong and sudden contraction of the abdomen during periextubation periextubation periods

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 15, 2026