Skip to content

Periprosthetic Fracture Following Tibial Echinococcosis

Periprosthetic Pathologic Fracture Following Tibial Echinococcosis: A Case Report

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT03622346
Enrollment
1
Registered
2018-08-09
Start date
2010-01-05
Completion date
2017-07-01
Last updated
2018-08-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cystic Echinococcus

Keywords

Echinococcosis, Hydatidosis, TKR, Fracture

Brief summary

Cystic Echinococcus in the bone is rare, comprising 0.5% to 2.5% of all human hydatidosis Association of Hydatid disease to pathologic fractures involving knee prosthesis have not yet been described A combined surgical and medical approach is of paramount importance to avoid recurrence Resulting osseus defects is challenging and require specific prosthesis when treating this entity.

Detailed description

Hydatid disease in humans caused by the parasitic tapeworm Echinococcus granulosus has an osseous involvement of about 0.5% to 2.5% of all cases in humans. The location of hydatid cysts in the tibia is seldom described in the medical literature, and its diagnosis and treatment is challenging. This paper presents a patient, with a long term, well tolerated, bilateral total knee arthroplasty (TKA), treated at our clinic, with a recent history of pain and oedema in her left upper leg. After achieving a, radiologically and histopathologically, well documented, diagnosis of Echinococcosis lesion in her left proximal tibia, a surgical intervention was planed, a wide resection of the cyst performed, and a specific anti-helmintic therapy was instituted. Four years later the patient returns to the investigators observation complaining of pain and unable to bear weight on her left knee, from which a pathologic fracture, adjacent to the tibial component was diagnosed. After surgical debridement of the newly advanced hydatid cyst growth, the TKA was revised, and due to the tibial component failure and the femoral implant loosening, a semi-constrained total knee revision arthroplasty was executed. Functional outcome was excellent. Although challenges in treatment of musculoskeletal hydatid cysts (HC) lesions have been documented, data regarding the musculoskeletal HC lesions resembling tumor is scarce, and those resulting in a prosthetic failure haven't been published. The authors intend to add data concerning the therapeutic approach to this entity.

Interventions

PROCEDURESemi-constrained total knee arthroplasty

Semi-constrained total knee arthroplasty

Sponsors

Centro Hospitalar do Medio Tejo
Lead SponsorOTHER

Study design

Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE

Intervention model description

Just one patient, subject to two surgeries: curettage and external fixation; subsequently the patient underwent total knee arthroplasty

Eligibility

Sex/Gender
FEMALE
Healthy volunteers
No

Inclusion criteria

* Patients with echinococcus infection * Patients which this infection compromises knee stability.

Exclusion criteria

* bacterial infection * immunocompromised patients

Design outcomes

Primary

MeasureTime frameDescription
Pain assessed by numerical rating scale (NRS)6 yearsmeasured with numerical rating scale (NRS), ranging from 0 to 10 (minimum to maximum pain)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026