Metabolic Syndrome, Vitiligo
Conditions
Keywords
insulin resistance
Brief summary
This study aims at detection of possible associated metabolic syndrome with vitiligo and assessment of possible contribution of the age of onset of vitiligo.
Detailed description
This study aims at detection of incidence of metabolic syndrome in vitiligo patients and possible contribution of the age of onset of the disease. This involves detection of waist circumference, body mass index, index of central obesity, systolic and diastolic arterial blood pressure, fasting blood sugar, high density lipoproteins and triglycerides, in addition to insulin resistance as Homeostatic Model Assessment- insulin resisitance (HOMA-IR) and serum leptin in vitiligo patients. The outcomes will be correlated to extent/ severity/duration/ activity of vitiligo as well as to the age of onset. This is assumed to be of profound impact on vitiligo patients by properly assessing these patients for associated metabolic risk factors and helping prevent such metabolic derangements by detection of possible contributing factors such as insulin resistance and high serum adipokines as leptin. Since there is temporal relation between nutrition, metabolic derangements and skin diseases where nutritional deficiencies as minerals, vitamins and fatty acids can lead to cutaneous manifestations and , on the other hand; skin diseases could contribute to metabolic derangements and nutritional deficiencies, the investigator's study will focus on nutrition and dietary habits and there possible contribution to any associated metabolic risk in vitiligo patients. This is likely to open new horizons in the management of vitiligo, possibly through control of metabolic syndrome risk factors and insulin resistance as well as revealing possible temporal relation to dietary habits that are overlooked in vitiligo patients.
Interventions
OTHERBlood sample
Blood sample for fasting blood sugar (FBS), High density lipoproteins (HDL), Triglycerides (TG) ,HOMA-IR, serum leptin
Sponsors
Cairo University
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
* Both genders * Patients with non-segmental vitiligo (NSV) and segmental vitiligo
Exclusion criteria
* Smoking * Pregnancy * Systemic steroid intake in the last 6 months
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Central obesity as a Metabolic risk in vitiligo patients | one year | Central obesity will be assessed using waist circumference in cm in vitiligo patients and control group as a risk factor for metabolic syndrome |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Arterial Blood Pressure as a Metabolic risk in vitiligo patients | one year | Arterial Blood Pressure will be assessed in vitiligo patients and control group as a risk factor for metabolic syndrome |
| Serum Triglycerides and HDL | one year | Serum Triglycerides and HDL will be assessed in vitiligo patients and control group as a risk factor for metabolic syndrome |
| Body mass index as a Metabolic risk in vitiligo patients | one year | Body Mass index in kg/m2 will be assessed in vitiligo patients and control group as a risk factor for metabolic syndrome |
| Fasting Blood pressure as a Metabolic risk in vitiligo patients | one year | Fasting Blood pressure will be assessed in vitiligo patients and control group as a risk factor for metabolic syndrome |
| Correlation between extent/ severity/duration/ activity of vitiligo and possible associated metabolic derangements. | one year | This via detecting VASI, VES and VIDA scores for vitiligo patients |
| Correlation between extent/ severity/duration/ activity of vitiligo and the age of onset. | one year | This via detecting VASI, VES and VIDA scores for vitiligo patients and relating to the age of onset |
| Detection of possible influence of dietary habits and its relation to metabolic derangements and disease progression | one year | This via directly addressing dietary habits |
| Detection of insulin resistance in patients with vitiligo | one year | This is via measuring HOMA-IR |
Countries
Egypt
Outcome results
None listed